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Table 3 Univariate and multivariate analysis to identify predictors for a higher psychosocial burden (PB) in caregivers in the total cohort, in patients with alcoholic liver cirrhosis, and in patients with non-alcoholic liver cirrhosis

From: Continued alcohol consumption and hepatic encephalopathy determine quality of life and psychosocial burden of caregivers in patients with liver cirrhosis

Variable Univariate analysis Multivariate analysis
r p value β p value
Total cohort     
 Continued alcohol consumption 0.324 0.001 0.280 0.020
 History of HE 0.390 < 0.001 0.234 0.010
 Health-related Quality of life of patients (CLDQ) − 0.419 < 0.001 − 0.199 0.030
 Quality of life of caregivers (SF-36) − 0.275 0.005 − 0.250 0.005
Alcoholic liver cirrhosis     
 Quality of life of patients (CLDQ) − 0.419 < 0.001 − 0.254 0.083
 Continued calcohol consumption 0.449 0.002 0.305 0.030
 History of HE 0.390 < 0.001 0.179 0.231
Non-alcoholic liver cirrhosis     
 Health-related quality of life of patients (CLDQ) − 0.4 0.002 0.263 0.039
 Quality of life of caregivers (SF 36) − 0.409 0.002 − 0.135 0.299
 History of HE 0.389 0.003 0.263 0.039
  1. Gender 1 for male, 2 for female; 1 for Alcohol consumption, 0 for no alcohol consumption; 1 for history of hepatic encephalopathy, 0 for no history of hepatic encephalopathy. Factors not predictive for ZBI in the univariate analysis were gender, age, age of caregiver, sodium, creatine, bilirubin, albumin, INR, CRP, leucocytes, hemoglobin, platelets, MELD, Child–Pugh status, history of ascites, history of spontaneously bacterial peritonitis, history of gastrointestinal bleeding, history of hepatorenal syndrome. With the remaining factors, a multivariate linear regression model with inclusion variable selection was built
  2. HE, hepatic encephalopathy; SF-36, short form health 36; INR, international standardized ratio; CRP, C-reactive protein