Table 8 Distribution-based estimates of MCTs for the Itch NRS, Skin Pain NRS, and ADSS items in BREEZE-AD1, BREEZE-AD2, and BREEZE-AD5

Itch NRS (scale 0–10)

BREEZE-AD1

0.42

1.04

1.67

0.88

BREEZE-AD2

0.43

1.09

1.74

0.89

BREEZE-AD5

0.43

1.09

1.74

0.92

Overall

0.43

1.07

1.72

0.89

Skin pain NRS (scale 0–10)

BREEZE-AD1

0.49

1.23

1.98

1.09

BREEZE-AD2

0.51

1.27

2.04

1.06

BREEZE-AD5

0.53

1.32

2.11

1.20

Overall

0.51

1.27

2.04

1.12

ADSS item 1 (scale 0–4)

BREEZE-AD1

0.22

0.54

0.86

0.49

BREEZE-AD2

0.22

0.56

0.90

0.49

BREEZE-AD5

0.24

0.60

0.95

0.52

Overall

0.23

0.57

0.90

0.50

ADSS item 2 (scale 0–29)

BREEZE-AD1

0.93

2.34

3.74

1.39

BREEZE-AD2

0.46

1.15

1.85

1.31

BREEZE-AD5

0.58

1.45

2.32

0.82

Overall

0.66

1.65

2.64

1.17

ADSS item 3 (scale 0–4)

BREEZE-AD1

0.19

0.47

0.76

0.48

BREEZE-AD2

0.19

0.49

0.78

0.52

BREEZE-AD5

0.19

0.47

0.76

0.51

Overall

0.19

0.48

0.77

0.50