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Table 6 Within group mean and median change scores for responsiveness of the itch NRS, skin pain NRS, and ADSS to change on the POEM between baseline and week 4 for BREEZE-AD1, BREEZE-AD2, and BREEZE-AD5

From: Psychometric properties of the itch numeric rating scale, skin pain numeric rating scale, and atopic dermatitis sleep scale in adult patients with moderate-to-severe atopic dermatitis

 

POEM groups at week 4

Much Improved (> 1 Category Improvement)

Improved (1 Category Improvement)

Stable (No Category Change)

Declined (≥ 1 Category Worsening)

Itch NRS

BREEZE-AD1

Sample size

63

191

301

26

Mean (SD) change

− 3.85 (1.943)

− 2.29 (1.779)

− 1.07 (1.629)

0.21 (1.942)

Median change

− 3.67

− 2.14

− 0.86

0.64

Between-group comparisonsa

< 0.0001

< 0.0001

0.0002

BREEZE-AD2

Sample size

69

190

286

23

Mean (SD) at baseline

− 3.90 (2.318)

− 2.45 (2.101)

− 1.08 (1.634)

0.14 (1.049)

Median change

− 3.71

− 2.29

− 0.86

0.17

Between-group comparisonsa

< 0.0001

< 0.0001

0.0030

BREEZE-AD5

Sample size

35

114

217

13

Mean (SD) at baseline

− 4.12 (2.261)

− 2.56 (2.059)

− 1.15 (1.627)

− 0.81 (1.569)

Median change

− 3.71

− 2.30

− 0.86

− 0.57

Between-group comparisonsa

0.0002

< 0.0001

0.9320

Skin pain NRS

BREEZE-AD1

Sample size

63

191

301

26

Mean (SD) change

− 3.49 (2.111)

− 2.24 (1.970)

− 0.97 (1.773)

0.31 (1.726)

Median change

− 3.14

− 1.86

− 0.71

0.48

Between-group comparisonsa

< 0.0001

< 0.0001

0.0007

BREEZE-AD2

Sample size

69

190

286

23

Mean (SD) at baseline

− 4.13 (2.412)

− 2.66 (2.290)

− 0.97 (1.826)

0.20 (1.206)

Median change

− 4.00

− 2.29

− 0.86

0.43

Between-group comparisonsa

< 0.0001

< 0.0001

0.0118

BREEZE-AD5

Sample size

35

114

217

13

Mean (SD) at baseline

− 4.24 (2.361)

− 2.49 (2.119)

− 1.19 (1.889)

− 0.38 (1.667)

Median change

− 4.00

− 2.15

− 0.90

− 0.57

Between-group comparisonsa

< 0.0001

< 0.0001

0.3379

ADSS item 1

BREEZE-AD1

Sample size

63

191

301

26

Mean (SD) change

− 1.31 (0.958)

− 0.75 (0.828)

− 0.42 (0.813)

0.31 (1.061)

Median change

− 1.29

− 0.71

− 0.29

0.00

Between-group comparisonsa

< 0.0001

< 0.0001

< 0.0001

BREEZE-AD2

Sample size

69

190

286

23

Mean (SD) at baseline

− 1.30 (0.886)

− 0.85 (0.894)

− 0.35 (0.823)

0.20 (0.507)

Median change

− 1.14

− 0.71

− 0.31

0.14

Between-group comparisonsa

0.0001

< 0.0001

0.0062

BREEZE-AD5

Sample size

35

114

217

13

Mean (SD) at baseline

− 1.49 (0.918)

− 0.88 (0.839)

− 0.46 (0.814)

− 0.12 (0.787)

Median change

− 1.43

− 0.88

− 0.29

0.00

Between-group comparisonsa

0.0014

< 0.0001

0.2903

ADSS item 2

BREEZE-AD1

Sample size

63

191

301

26

Mean (SD) change

− 1.85 (2.836)

− 1.45 (3.027)

− 0.70 (2.119)

0.35 (2.133)

Median change

− 1.00

− 0.71

− 0.43

0.15

Between-group comparisonsa

0.2945

0.0019

0.0375

BREEZE-AD2

Sample size

69

190

286

23

Mean (SD) at baseline

− 1.34 (1.490)

− 1.12 (2.629)

− 0.52 (2.105)

0.12 (0.601)

Median change

− 0.86

− 0.56

− 0.43

0.00

Between-group comparisonsa

0.3931

0.0096

0.1092

BREEZE-AD5

Sample size

35

114

217

13

Mean (SD) at baseline

− 1.66 (1.522)

− 1.13 (1.365)

− 0.54 (1.208)

0.06 (0.791)

Median change

− 1.29

− 0.67

− 0.31

0.29

Between-group comparisonsa

0.1450

0.0001

0.1491

ADSS item 3

BREEZE-AD1

Sample size

20

80

201

9

Mean (SD) change

− 1.15 (1.024)

− 0.73 (0.833)

− 0.31 (0.807)

0.27 (0.843)

Median change

− 1.21

− 0.66

− 0.20

0.29

Between-group comparisonsa

0.0468

0.0002

0.0500

BREEZE-AD2

Sample size

19

72

165

13

Mean (SD) at baseline

− 1.27 (0.700)

− 0.70 (0.814)

− 0.24 (0.849)

0.05 (0.472)

Median change

− 1.26

− 0.60

− 0.29

0.00

Between-group comparisonsa

0.0069

< 0.0001

0.2670

BREEZE-AD5

Sample size

14

48

138

7

Mean (SD) at baseline

− 1.54 (0.856)

− 1.05 (0.739)

− 0.41 (0.749)

− 0.47 (1.075)

Median change

− 1.38

− 1.00

− 0.36

− 0.29

Between-group comparisonsa

0.1086

< 0.0001

0.6526

  1. ADSS, Atopic dermatitis sleep scale, ANOVA, analysis of variance; NRS, numeric rating scale; POEM, patient oriented eczema measure; SD, standard deviation
  2. aBetween-group comparisons. The p value for the pairwise comparisons between consecutive severity groups was derived from an ANOVA assessing differences in score change between groups