Measure | Study | Baseline to Week 1 | Week 4 to Week 8 | ||
---|---|---|---|---|---|
N | ICCa (95% CI) | N | ICCa (95% CI) | ||
Itch NRS | BREEZE-AD1 | 620 | 0.863 (0.842, 0.882) | 599 | 0.783 (0.750, 0.812) |
BREEZE-AD2 | 608 | 0.853 (0.830, 0.873) | 587 | 0.816 (0.787, 0.841) | |
BREEZE-AD5 | 432 | 0.875 (0.851, 0.896) | 405 | 0.770 (0.727, 0.807) | |
Skin pain NRS | BREEZE-AD1 | 620 | 0.832 (0.806, 0.855) | 599 | 0.773 (0.739, 0.804) |
BREEZE-AD2 | 608 | 0.845 (0.821, 0.866) | 587 | 0.808 (0.778, 0.834) | |
BREEZE-AD5 | 432 | 0.832 (0.801, 0.859) | 405 | 0.753 (0.708, 0.792) | |
ADSS item 1 | BREEZE-AD1 | 620 | 0.839 (0.814, 0.861) | 599 | 0.754 (0.717, 0.786) |
BREEZE-AD2 | 607 | 0.843 (0.819, 0.865) | 587 | 0.776 (0.742, 0.806) | |
BREEZE-AD5 | 432 | 0.834 (0.803, 0.861) | 405 | 0.792 (0.753, 0.826) | |
ADSS item 2 | BREEZE-AD1 | 620 | 0.921 (0.908, 0.932) | 599 | 0.903 (0.887, 0.917) |
BREEZE-AD2 | 607 | 0.765 (0.730, 0.796) | 587 | 0.585 (0.529, 0.635) | |
BREEZE-AD5 | 432 | 0.921 (0.906, 0.934) | 405 | 0.918 (0.901, 0.932) | |
ADSS item 3 | BREEZE-AD1 | 512 | 0.780 (0.743, 0.811) | 353 | 0.703 (0.646, 0.752) |
BREEZE-AD2 | 497 | 0.761 (0.722, 0.796) | 315 | 0.682 (0.618, 0.737) | |
BREEZE-AD5 | 369 | 0.784 (0.741, 0.820) | 239 | 0.671 (0.596, 0.735) |