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Table 2 Test–retest reliability assessment of itch NRS, skin pain NRS and ADSS for BREEZE-AD1, BREEZE-AD2, and BREEZE-AD5

From: Psychometric properties of the itch numeric rating scale, skin pain numeric rating scale, and atopic dermatitis sleep scale in adult patients with moderate-to-severe atopic dermatitis

Measure

Study

Baseline to Week 1

Week 4 to Week 8

N

ICCa (95% CI)

N

ICCa (95% CI)

Itch NRS

BREEZE-AD1

620

0.863 (0.842, 0.882)

599

0.783 (0.750, 0.812)

BREEZE-AD2

608

0.853 (0.830, 0.873)

587

0.816 (0.787, 0.841)

BREEZE-AD5

432

0.875 (0.851, 0.896)

405

0.770 (0.727, 0.807)

Skin pain NRS

BREEZE-AD1

620

0.832 (0.806, 0.855)

599

0.773 (0.739, 0.804)

BREEZE-AD2

608

0.845 (0.821, 0.866)

587

0.808 (0.778, 0.834)

BREEZE-AD5

432

0.832 (0.801, 0.859)

405

0.753 (0.708, 0.792)

ADSS item 1

BREEZE-AD1

620

0.839 (0.814, 0.861)

599

0.754 (0.717, 0.786)

BREEZE-AD2

607

0.843 (0.819, 0.865)

587

0.776 (0.742, 0.806)

BREEZE-AD5

432

0.834 (0.803, 0.861)

405

0.792 (0.753, 0.826)

ADSS item 2

BREEZE-AD1

620

0.921 (0.908, 0.932)

599

0.903 (0.887, 0.917)

BREEZE-AD2

607

0.765 (0.730, 0.796)

587

0.585 (0.529, 0.635)

BREEZE-AD5

432

0.921 (0.906, 0.934)

405

0.918 (0.901, 0.932)

ADSS item 3

BREEZE-AD1

512

0.780 (0.743, 0.811)

353

0.703 (0.646, 0.752)

BREEZE-AD2

497

0.761 (0.722, 0.796)

315

0.682 (0.618, 0.737)

BREEZE-AD5

369

0.784 (0.741, 0.820)

239

0.671 (0.596, 0.735)

  1. ADSS, Atopic Dermatitis Sleep Scale; CI, confidence interval; ICC, intra-class correlation coefficient; N, number of total patients, NRS, numeric rating scale
  2. aAn ICC of 0.70 and above is considered acceptable agreement