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Table 2 Characteristics of health utility scores and EQ-VAS scores in different subgroups

From: Health-related quality of life in amyotrophic lateral sclerosis using EQ-5D-5L

  Groups Number Health utility score
Median, (IQR)
P value EQ-VAS score
Median, (IQR)
P value
Age of onset > 45 390 0.74 (0.57, 0.88) 0.026* 70.0 (50.0, 80.0) 0.542
< 45 113 0.80 (0.63, 0.91) 70.0 (60.0, 80.0)
Sex Male 319 0.78 (0.58, 0.91) 0.055 70.0 (50.0, 80.0) 0.221
female 184 0.73 (0.57, 0.87) 70.0 (50.0, 80.0)
Onset region Bulbar onset 62 0.90 (0.80, 1.00) < 0.001* 70.0 (60.0, 80.0) 0.019*
Spinal onset 441 0.73 (0.56, 0.86) 70.0 (50.0, 80.0)
ALSFRS-R score ≥ 40 378 0.80 (0.67, 0.91) < 0.001* 70.0 (60.0, 80.0) < 0.001*
< 40 125 0.53 (0.31, 0.68) 55.0 (50.0, 70.0)
Stages 1 224 0.85 (0.69, 0.93) < 0.001* 70.0 (60.0, 80.0) < 0.001*
2 193 0.69 (0.51, 0.84) 65.0 (50.0, 80.0)
3 86 0.66 (0.44, 0.79) 60.0 (50.0, 70.0)
FAB ≥ 16 335 0.78 (0.59, 0.91) 0.017* 70.0 (55.0, 80.0) 0.026*
< 16 168 0.73 (0.56, 0.86) 60.0 (50.0, 80.0)
ACE-R ≥ 75 332 0.78 (0.59, 0.89) 0.055 70.0 (51.2, 80.0) 0.097
< 75 171 0.73 (0.54, 0.88) 60.0 (50.0, 80.0)
Depression > 7 238 0.65 (0.46, 0.78) < 0.001* 60.0 (50.0, 70.0) < 0.001*
≤ 7 265 0.85 (0.73, 0.93) 75.0 (60.0, 80.0)
Anxiety > 7 150 0.63 (0.44, 0.74) < 0.001* 60.0 (50.0, 70.0) < 0.001*
≤ 7 353 0.80 (0.65, 0.91) 70.0 (60.0, 80.0)
EDS ≥ 10 78 0.78 (0.58, 0.86) 0.663 60.0 (50.0, 80.0) 0.001*
< 10 425 0.77 (0.57, 0.89) 70.0 (57.5, 80.0)
RBD ≥ 5 31 0.69 (0.54, 0.84) 0.215 60.0 (50.0, 70.0) 0.033*
< 5 472 0.78 (0.58, 0.89) 70.0 (50.0, 80.0)
PSQI > 5 183 0.71 (0.55, 0.85) 0.001* 65.0 (50.0, 80.0) 0.244
≤ 5 320 0.78 (0.60, 0.91) 70.0 (51.3, 80.0)
  1. *Significant difference
  2. IQR, interquartile range; VAS, visual analog scale; B, bulbar onset; UL, upper limb; LL, lower limb; ALSFRS-R, Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised; FAB, frontal assessment battery; ACE-R, Addenbrooke’s Cognitive Examination-Revised; EDS, excessive daytime sleepiness; RBD, rapid eye movement sleep behavioral disorder; PSQI, Pittsburgh Sleep Quality Index