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Table 2 Characteristics of health utility scores and EQ-VAS scores in different subgroups

From: Health-related quality of life in amyotrophic lateral sclerosis using EQ-5D-5L

 

Groups

Number

Health utility score

Median, (IQR)

P value

EQ-VAS score

Median, (IQR)

P value

Age of onset

> 45

390

0.74 (0.57, 0.88)

0.026*

70.0 (50.0, 80.0)

0.542

< 45

113

0.80 (0.63, 0.91)

70.0 (60.0, 80.0)

Sex

Male

319

0.78 (0.58, 0.91)

0.055

70.0 (50.0, 80.0)

0.221

female

184

0.73 (0.57, 0.87)

70.0 (50.0, 80.0)

Onset region

Bulbar onset

62

0.90 (0.80, 1.00)

< 0.001*

70.0 (60.0, 80.0)

0.019*

Spinal onset

441

0.73 (0.56, 0.86)

70.0 (50.0, 80.0)

ALSFRS-R score

≥ 40

378

0.80 (0.67, 0.91)

< 0.001*

70.0 (60.0, 80.0)

< 0.001*

< 40

125

0.53 (0.31, 0.68)

55.0 (50.0, 70.0)

Stages

1

224

0.85 (0.69, 0.93)

< 0.001*

70.0 (60.0, 80.0)

< 0.001*

2

193

0.69 (0.51, 0.84)

65.0 (50.0, 80.0)

3

86

0.66 (0.44, 0.79)

60.0 (50.0, 70.0)

FAB

≥ 16

335

0.78 (0.59, 0.91)

0.017*

70.0 (55.0, 80.0)

0.026*

< 16

168

0.73 (0.56, 0.86)

60.0 (50.0, 80.0)

ACE-R

≥ 75

332

0.78 (0.59, 0.89)

0.055

70.0 (51.2, 80.0)

0.097

< 75

171

0.73 (0.54, 0.88)

60.0 (50.0, 80.0)

Depression

> 7

238

0.65 (0.46, 0.78)

< 0.001*

60.0 (50.0, 70.0)

< 0.001*

≤ 7

265

0.85 (0.73, 0.93)

75.0 (60.0, 80.0)

Anxiety

> 7

150

0.63 (0.44, 0.74)

< 0.001*

60.0 (50.0, 70.0)

< 0.001*

≤ 7

353

0.80 (0.65, 0.91)

70.0 (60.0, 80.0)

EDS

≥ 10

78

0.78 (0.58, 0.86)

0.663

60.0 (50.0, 80.0)

0.001*

< 10

425

0.77 (0.57, 0.89)

70.0 (57.5, 80.0)

RBD

≥ 5

31

0.69 (0.54, 0.84)

0.215

60.0 (50.0, 70.0)

0.033*

< 5

472

0.78 (0.58, 0.89)

70.0 (50.0, 80.0)

PSQI

> 5

183

0.71 (0.55, 0.85)

0.001*

65.0 (50.0, 80.0)

0.244

≤ 5

320

0.78 (0.60, 0.91)

70.0 (51.3, 80.0)

  1. *Significant difference
  2. IQR, interquartile range; VAS, visual analog scale; B, bulbar onset; UL, upper limb; LL, lower limb; ALSFRS-R, Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised; FAB, frontal assessment battery; ACE-R, Addenbrooke’s Cognitive Examination-Revised; EDS, excessive daytime sleepiness; RBD, rapid eye movement sleep behavioral disorder; PSQI, Pittsburgh Sleep Quality Index
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Health and Quality of Life Outcomes

ISSN: 1477-7525

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