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Table 1 Demographic and clinical variables according to King’s college stages

From: Health-related quality of life in amyotrophic lateral sclerosis using EQ-5D-5L

  Total
(n = 547)
Stage 1
(n = 224)
Stage 2
(n = 193)
Stage 3
(n = 86)
Stage 4
(n = 44)
P value
Age, years (M (SD)) 54.7 (11.4) 54.0 (11.0) 55.1 (11.8) 55.1 (12.7) 55.5 (9.5) 0.796
Male (n, (%)) 347 (63.4) 153 (68.3) 114 (59.1) 52 (60.5) 28 (63.6) 0.240
Education, years (M (SD)) 9.4 (3.6) 9.7 (3.8) 9.1 (3.4) 8.8 (3.4) 9.5 (3.7) 0.081
Age at onset, years (M (SD)) 53.4 (11.4) 52.8 (11.1) 53.8 (11.7) 53.9 (12.6) 53.8 (9.5) 0.865
Disease duration, months (M (SD)) 15.5 (14.4) 15.1 (14.3) 15.2 (14.3) 14.5 (13.2) 20.7 (16.5) 0.049
Diagnostic delay, months (M (SD)) 14.6 (14.0) 14.3 (13.6) 14.3 (14.1) 13.6 (13.1) 20.1 (16.6) 0.034
Onset region (B, UL, LL) 68, 273, 206 30, 109, 85 22, 96, 75 10, 47, 29 6, 21,17 0.967
ALSFRS-R score, (M (SD) 41.4 (4.4) 44.4 (2.4) 40.8 (3.4) 37.6 (4.2) 36.4 (5.1) < 0.001*
BMI, M (SD) 22.6 (3.1) 22.8 (3.1) 22.5 (3.2) 22.5 (3.1) 22.5 (3.2) 0.806
  1. ALSFRS-R, Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised; B, bulbar onset; UL, upper limb; LL, lower limb; BMI, body mass index; M, mean; SD, standard deviation
  2. *Significant difference. P values were Bonferroni-adjusted