Exploration of the methods of establishing the minimum clinical important difference based on anchor and its application in the quality of life measurement scale QLICP-ES (V2.0) for esophageal cancer

Table 5 The MCID of QLICP-ES (V2.0) determined by Multiple linear regression in standard B (n_B = 220)

_Domain	_MCID	_P	R²	_{Multiple linear regression model}
PHD	_13.9	_{< 0.001}	_0.36	\(d_{{change}}\) = − 26.36 − 0.03x₁ − 0.73x₂ − 0.38x₃ + 1.62x₄ + 19.76x₅ + 0.35x₆
PSD	_3.3	_0.002	_0.07	\(d_{{change}}\) = − 13.37 + 0.08x₁ + 0.22x₂ + 0.63x₃ − 2.10x₄ − 1.72x₅ + 0.21x₆
SOD	_3.0	_0.002	_0.07	\(d_{{change}}\) = − 7.83 + 0.71x₁ − 0.66x₂- − 0.46x₃ + 1.45x₄ + 6.53x₅ + 0.06x₆
_SSD	_5.6	_{< 0.001}	_0.13	\(d_{{change}}\) = 15.90 + 1.39x₁ − 0.48x₂ + 0.20x₃ − 0.79x₄ + 8.57x₅ + 0.20x₆
_CGM	_4.5	_{< 0.001}	_0.18	\(d_{{change}}\) = 1.53 + 1.07x₁ − 0.63x₂ + 0.08x₃ + 0.50x₄ + 7.72x₅ − 0.05x₆
_SPD	_7.4	_{< 0.001}	_0.12	\(d_{{change}}\) = − 2.42 + 0.79x₁ + 0.18x₂ − 0.26x₃ + 0.43x₄ + 7.92x₅ + 0.04x₆
TOT	_5.5	_{< 0.001}	_0.21	\(d_{{change}}\) = − 1.25 + 0.98x₁ − 0.33x₂ − 0.05x₃ + 0.43x₄ + 7.91x₅ + 0.01x₆

\(d_{{change}}\): the score difference between two measuring points, × 1: gender (male = 0, female = 1), × 2: age (≦ 60 = 0, > 60 = 1), × 3: education (Primary = 1, middle = 2, high or technical secondary school = 3, junior college = 4, bachelor degree or above = 5), × 4: family economy (poor = 1, medium = 2, rich = 3), × 5: group (no change = 0, Change by more than one level = 1), × 6: field base points
PHD physical domain, PSD psychological domain, SOD social domain, SSD common symptoms and side effect domain, CGM core/general module, SPD specific domain, TOT total

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