standard A, anchor-based method > ROC curve method > multiple linear regression models. The recommended MCID values of physical domain, psychological domain, social domain, common symptom and side-effects domain, the specific domain and the overall of the QLICP-ES were 7.8, 9.7, 4.7, 3.6, 4.3, 2.3 and 2.9, respectively. Conclusion Different methods have their own advantages and disadvantages, and also different definitions and standards can be adopted according to research purposes and methods. A lot of different MCID values were presented in this paper so that it can be easy and convenient to select by users."/>
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Table 5 The MCID of QLICP-ES (V2.0) determined by Multiple linear regression in standard B (nB = 220)

From: Exploration of the methods of establishing the minimum clinical important difference based on anchor and its application in the quality of life measurement scale QLICP-ES (V2.0) for esophageal cancer

Domain MCID P R2 Multiple linear regression model
PHD 13.9 < 0.001 0.36 \(d_{{change}}\) =  − 26.36 − 0.03x1 − 0.73x2 − 0.38x3 + 1.62x4 + 19.76x5 + 0.35x6
PSD 3.3 0.002 0.07 \(d_{{change}}\) =  − 13.37 + 0.08x1 + 0.22x2 + 0.63x3 − 2.10x4 − 1.72x5 + 0.21x6
SOD 3.0 0.002 0.07 \(d_{{change}}\) =  − 7.83 + 0.71x1 − 0.66x2- − 0.46x3 + 1.45x4 + 6.53x5 + 0.06x6
SSD 5.6 < 0.001 0.13 \(d_{{change}}\) = 15.90 + 1.39x1 − 0.48x2 + 0.20x3 − 0.79x4 + 8.57x5 + 0.20x6
CGM 4.5 < 0.001 0.18 \(d_{{change}}\) = 1.53 + 1.07x1 − 0.63x2 + 0.08x3 + 0.50x4 + 7.72x5 − 0.05x6
SPD 7.4 < 0.001 0.12 \(d_{{change}}\) =  − 2.42 + 0.79x1 + 0.18x2 − 0.26x3 + 0.43x4 + 7.92x5 + 0.04x6
TOT 5.5 < 0.001 0.21 \(d_{{change}}\) =  − 1.25 + 0.98x1 − 0.33x2 − 0.05x3 + 0.43x4 + 7.91x5 + 0.01x6
  1. \(d_{{change}}\): the score difference between two measuring points, × 1: gender (male = 0, female = 1), × 2: age ( 60 = 0, > 60 = 1), × 3: education (Primary = 1, middle = 2, high or technical secondary school = 3, junior college = 4, bachelor degree or above = 5), × 4: family economy (poor = 1, medium = 2, rich = 3), × 5: group (no change = 0, Change by more than one level = 1), × 6: field base points
  2. PHD physical domain, PSD psychological domain, SOD social domain, SSD common symptoms and side effect domain, CGM core/general module, SPD specific domain, TOT total