Exploration of the methods of establishing the minimum clinical important difference based on anchor and its application in the quality of life measurement scale QLICP-ES (V2.0) for esophageal cancer

Table 4 The MCID of QLICP-ES (V2.0) determined by Multiple linear regression in standard A (n_A = 157)

_Domain	_MCID	_P	R²	_{Multiple linear regression model}
PHD	_9.0	_{< 0.001}	_0.27	\(d_{{change}}\) = − 15.46 − 2.81x₁ + 1.01x₂ − 1.21x₃ + 4.05x₄ + 16.37x₅ + 0.13x₆
PSD	_3.0	_0.027	_0.05	\(d_{{change}}\) = − 5.60 + 3.24x₁ − 0.14x₂ + 0.67x₃ − 2.86x₄ − 2.51x₅ + 0.12x₆
SOD	_1.2	_{< 0.001}	_0.12	\(d_{{change}}\) = 3.72 − 1.36x₁ − 0.61x₂ − 0.25x₃ + 3.81x₄ + 4.42x₅ − 0.17x₆
_SSD	_4.0	_{< 0.001}	_0.22	\(d_{{change}}\) = 24.16 + 3.24x₁ − 1.13x₂ − 0.62x₃ − 0.06x₄ + 6.65x₅ − 0.29x₆
_CGM	_2.6	_{< 0.001}	_0.22	\(d_{{change}}\) = 9.07 + 0.90x₁ + 0.08x₂ − 0.28x₃ + 1.53x₄ + 5.38x₅ − 0.18x₆
_SPD	_5.9	_<0.001	_0.12	\(d_{{change}}\) = 3.13 + 1.26x₁ + 0.50x₂ − 0.35x₃ + 0.90x₄ + 7.23x₅ − 0.04x₆
TOT	_3.7	_{< 0.001}	_0.22	\(d_{{change}}\) = 3.86 + 0.93x₁ + 0.27x₂ − 0.33x₃ + 1.13x₄ + 6.23x₅ − 0.08x₆

\(d_{{change}}\): the score difference between two measuring points, × 1: gender (male = 0, female = 1), × 2: age (≦ 60 = 0, > 60 = 1), × 3: education (Primary = 1, middle = 2, high or technical secondary school = 3, junior college = 4, bachelor degree or above = 5), × 4: family economy (poor = 1, medium = 2, rich = 3), × 5: group (no change = 0, Change a level = 1), × 6: field base points
PHD physical domain, PSD psychological domain, SOD social domain, SSD common symptoms and side effect domain, CGM core/general module, SPDspecific domain, TOT total

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