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Table 1 Characteristics of the studies on health-related quality of life in children and adolescents with idiopathic nephrotic syndrome

From: Reliability of generic quality-of-life instruments in assessing health-related quality of life among children and adolescents with idiopathic nephrotic syndrome: a systematic review

Study (first author’s name and year of publication)

Country of study

Study setting

Study population (sample size and age/sex distribution)

Study design

Rüth et al. [21]

Switzerland

Zurich University hospital

45 subjects/controls

Median ages at diagnosis: 9.8 years (3.4–19.8 years) for subjects and 5.9 years (0.1–16.3 years) for controls

Cross-sectional, case–control study

Selewski et al. [22]

United States

Multi-center setting (Midwest Pediatric Nephrology Consortium)

127 subjects (67 with prevalent NS and 60 with incident NS)

Age range: 8–12 years (67 subjects) and 13–17 years (60 subjects)

Male/Female (83 subjects/44 subjects)

Longitudinal cohort study

Rahman et al. [15]

Bangladesh

Dhaka Medical College Hospital

50 subjects

Age range: 2–12 years (mean age: 7 ± 2.92 years)

Male/Female (29 subjects/21 subjects)

Prospective cross-sectional study

Agrawal et al. [17]

India

Tertiary health facility in southern India

50 subjects and 50 controls

Age range: 2–18 years

Male/Female (30 subjects or controls/20 subjects or controls)

Cross-sectional, case–control study

Khanjari et al. 23]

Iran

Ali Asghar & Pediatric Medical Centers

Mofid hospital, Tehran

38 subjects and 38 controls

Age range: 8–12 years (mean age: 9.63 ± 1.49 years for subjects, 9.42 ± 1.51 years for controls)

Male/Female (25/13 subjects and 26/12 controls)

A prospective, case–control study

Roussel et al. [16]

France

Pediatric Nephrology centers in France

110 subjects

Age range:7–17 years (mean age: 11.6 years)

Cross-sectional observational study

Troost et al. [24]

United States

Canada

Multi-center tertiary health-facility settings in the United States and Canada

56 subjects with incident INS* & 65 subjects with prevalent INS‡ (PROMIS-II)

87 subjects with incident INS & 172 prevalent INS (NEPTUNE)

Age ranges: 8–17 years (children)

 > 18 years (adults)

Longitudinal cohort study (PROMIS-II and NEPTUNE)

Solarin et al. [25]

Nigeria

Tertiary health facility in Lagos

61 subjects

Age range: 2–18 years (mean age: 5 ± 3.39 years)

Male/Female (37 subjects/24 subjects)

A prospective, cross-sectional study

Jabbar et al. [26]

Iraq

Pediatric clinics at two hospitals in Baghdad

50 subjects/50 controls

Age range:2–12 years

Prospective case–control study

Eid et al. [10]

Egypt

Mansoura University Children’s hospital

300 subjects (100 subjects with INS & 200 matched controls: healthy & chronic non-renal illness groups)

Prospective case–control study

  1. PROMIS-II, Patient-reported outcomes measurement information systems II; NEPTUNE, Nephrotic syndrome study network consortium; INS, idiopathic nephrotic syndrome; *Disease duration at baseline < 30 days; ‡Disease duration at baseline ≥ 30 days