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Table 2 Predictors of WHOQoL-HIV BREF component 12 weeks after DAA treatment

From: Impact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis C and human immunodeficiency virus

 

Level of independence

Environment

Spiritual/religion/personal beliefs

Overall perception of QoL

Overall perception of health

Bivariate

Multivariate

Bivariate

Multivariate

Bivariate

Multivariate

Bivariate

Multivariate

Bivariate

Multivariate

RR, (95% CI)

p

RR (95% CI)

p

RR (95% CI)

p

RR (95% CI)

p

RR (95% CI)

p

RR (95% CI)

p

RR (95% CI)

p

RR (95% CI)

p

RR (95% CI)

p

RR (95% CI)

p

Male gender

2.56 (0.91–7.22)

0.050

4.01 (1.09–14.74)

0.037

0.86 (0.57–1.29)

0.677

  

1.12 (0.52–2.40)

0.992

  

1.49 (0.52–4.28)

0.559

  

1.36 (0.57–3.30)

0.654

  

Age ≤ 40 year

1.02 (0.69–1.52)

1.000

  

1.09 (0.78–1.53)

0.735

  

1.50 (0.85–2.63)

0.203

1.88 (0.83–4.26)

0.130

0.84 (0.48–1.48)

0.702

  

0.93 (0.57–1.52)

0.918

  

University education

0.84 (0.58–1.23)

0.462

  

0.96 (0.71–1.29)

0.901

  

0.84 (0.53–1.34)

0.581

  

0.71 (0.40–1.25)

0.306

  

1.07 (0.67–1.70)

0.911

  

Married versus not married

1.50 (0.69–3.26)

0.407

  

0.83 (0.39–1.79)

0.334

  

1.06 (0.47–2.42)

0.496

  

0.97 (0.42–2.25)

0.604

  

1.05 (0.47–2.35)

0.529

  

Married versus Widow/divorce

1.71 (0.65–4.50)

0.407

  

0.48 (0.18–1.29)

0.334

  

0.59 (0.23–1.53)

0.496

  

1.77 (0.54–5.77)

0.604

  

1.86 (0.62–5.53)

0.529

  

Regular worker versus non-regular

0.57 (0.28–1.17)

0.127

0.62 (0.29–1.31)

0.215

1.25 (0.62–2.55)

0.735

  

1.13 (0.54–2.34)

0.933

  

1.46 (0.66–3.22)

0.383

  

1.90 (0.89–4.08)

0.249

1.99 (0.89–4.44)

0.094

Regular worker versus not working

1.45 (0.52–4.06)

0.127

0.77 (0.23–2.56)

0.663

0.90 (0.33–2.41)

0.735

  

0.96 (0.35–2.65)

0.933

  

2.14 (0.64–7.17)

0.383

  

1.45 (0.52–4.06)

0.249

1.20 (0.41–3.58)

0.738

CD4 > 500 versus 350–500

1.47 (0.57–3.82)

0.636

  

0.71 (0.28–1.81)

0.772

  

1.04 (0.39–2.79)

0.944

  

0.65 (0.24–1.80)

0.787

  

0.75 (0.28–1.99)

0.882

  

CD4 > 500 versus < 350

0.79 (0.37–1.72)

0.636

  

0.77 (0.35–1.67)

0.772

  

0.82 (0.37–1.85)

0.944

  

0.71 (0.30–1.69)

0.787

  

0.79 (0.35–1.80)

0.882

  

HCV-RNA > 800,000 IU/mL

1.02 (0.66–1.57)

1.000

  

1.04 (0.73–1.49)

0.992

  

0.87 (0.53–1.44)

0.749

  

0.55 (0.32–0.93)

0.054

0.42 (0.18–0.94)

0.035

0.67 (0.42–1.08)

0.177

0.59 (0.25–1.38)

0.225

Interferon failure

1.03 (0.56–1.91)

1.000

  

0.54 (0.24–1.24)

0.132

0.34 (0.10–1.15)

0.083

0.42 (0.12–1.54)

0.220

0.36 (0.07–1.80)

0.215

1.16 (0.49–2.75)

0.748

  

0.92 (0.39–2.16)

1,000

  

Achieving SVR12

1.60 (0.49–5.23)

0.460

  

1.29 (0.54–3.06)

0.702

  

0.58 (0.29–1.16)

0.234

0.27 (0.05–1.45)

0.130

1.93 (0.31–12.07)

0.675

  

1.17 (0.35–3.85)

1,000

  

Non-smoker

0.92 (0.64–1.33)

0.796

  

0.81 (0.60–1.09)

0.214

0.65 (0.33–1.26)

0.197

0.62 (0.39–0.99)

0.234

0.46 (0.23–0.95)

0.035

1.18 (0.69–2.03)

0.671

  

0.46 (0.28–0.77)

0.003

0.32 (0.15–0.66)

0.002

BMI normal versus underweight

0.71 (0.27–1.91)

0.001

0.75 (0.28–2.03)

0.572

0.63 (0.23–1.72)

0.554

  

0.70 (0.26–1.90)

0.685

  

0.60 (0.22–1.64)

0.108

0.56 (0.20–1.57)

0.274

0.70 (0.26–1.90)

0.778

  

BMI normal versus overweight/obese

4.99 (1.88–13.19)

0.001

4.80 (1.79–12.81)

0.002

1.17 (0.53–2.57)

0.554

  

0.76 (0.33–1.72)

0.685

  

2.32 (0.81–6.65)

0.108

2.37 (0.81- 6.90

0.114

0.98 (0.42–2.27)

0.778

  

Non-IVDU

0.67 (0.32–1.42)

0.373

  

0.91 (0.54–1.52)

0.908

  

0.70 (0.29–1.69)

0.571

  

0.92 (0.38–2.25)

1,000

  

0.94 (0.44–2.02)

1,000

  

Fibrosis stage F0–F1 versus F2–F3

1.09 (0.47–2.51)

0.982

  

1.01 (0.44–2.34)

0.506

  

0.69 (0.29–1.62)

0.631

  

1.06 (0.40–2.83)

0.323

  

1.67 (0.64–4.35)

0.332

  

Fibrosis stage F0–F1 versus F4

1.02 (0.44–2.38)

0.982

  

1.63 (0.70–3.80)

0.506

  

0.75 (0.31–1.80)

0.631

  

0.53 (0.22–1.30)

0.323

  

0.72 (0.30–1.71)

0.332

  

Non-anemia

1.30 (0.74–2.26)

0.451

  

1.29 (0.81–2.06)

0.349

  

0.95 (0.53–1.69)

1.000

  

1.15 (0.54–2.44)

0.912

  

1.22 (0.62–2.40)

0.717

  

NNRTI-based versus PI-based ART

1.07 (0.61–1.88)

0.993

  

1.34 (0.77–2.32)

0.360

  

3.62 (0.96–13.68)

0.036

5.23 (1.16–23.65)

0.032

1.81 (0.62–5.30)

0.371

  

2.26 (0.78–6.56)

0.145

3.26 (0.87–12.18)

0.078

  1. HCV-RNA: hepatitis C virus ribonucleic acid; SVR12: sustained virological response at 12 weeks post treatment; BMI: body mass index; IVDU: intravenous drug user; NNRTI: non-nucleoside reverse transcriptase inhibitor; PI: protease inhibitor; ART: antiretroviral therapy