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Table 4 Performance of the EQ-5D-3L in screening for anxiety symptoms (GAD-2 ≥ 3)

From: The performance of the EQ-5D-3L in screening for anxiety and depressive symptoms in hospital and community settings

Cut-point Hospital setting (N = 492) Community setting (N = 400)
 ≥ 2  ≥ 3  ≥ 2  ≥ 3
EQ-5D-3L Anxiety/depression dimension     
Sensitivity 75.0% 17.7% 74.6% 14.9%
Specificity 69.8% 98.0% 82.6% 98.2%
LR+  2.48 9.00 4.28 8.28
LR− 0.36 0.84 0.31 0.87
PPV 48.0% 76.6% 45.0% 61.2%
NPV 88.3% 76.3% 94.5% 85.8%
AUROC (95% CI) 0.74 (0.70, 0.79) 0.79 (0.74, 0.85)
EQ-5D-3L index score tertiles     
Sensitivity 52.2% 14.7% 25.4% 4.5%
Specificity 30.3% 62.8% 34.4% 68.3%
LR+  0.75 0.39 0.39 0.14
LR− 1.58 1.36 2.17 1.40
PPV 21.7% 12.8% 6.9% 2.6%
NPV 63.2% 66.6% 70.8% 79.0%
AUROC (95% CI) 0.37 (0.32, 0.42) 0.27 (0.22, 0.33)
EQ-VAS score tertiles     
Sensitivity 52.9% 13.2% 41.8% 10.5%
Specificity 32.4% 73.0% 30.5% 68.0%
LR+ 0.78 0.49 0.60 0.33
LR− 1.45 1.19 1.91 1.32
PPV 22.5% 15.3% 10.3% 5.9%
NPV 65.0% 69.5% 73.3% 80.0%
AUROC (95% CI) 0.40 (0.33, 0.47) 0.33 (0.27, 0.39)
  1. LR+, positive likelihood ratio; LR−, negative likelihood ratio; AUROC, area under receiver operating curve. EQ-5D-3L index score tertiles: 2 = quintile 2, 3 = quintile 3. EQ-5D-3L anxiety/depression dimension: 2 = moderately anxious or depressed, 3 = extremely anxious or depressed. PPV, positive predictive value; NPV, negative predictive value. Bolded values indicate the cut-point that maximizes sensitivity and specificity for each component