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Table 2 Epidemiological background and clinical characteristics of our study population regarding the prevalence of ICU infections [due to either ABRP (N = 58) or non-ABRP (N = 57)] or not (N = 236)

From: The role of antimicrobial resistance on long-term mortality and quality of life in critically ill patients: a prospective longitudinal 2-year study

  ABRP infections
N = 58 		Non-ABRP infections
N = 57 		No infections
N = 236 		P-value
Age, years 66 ± 14.1 66.8 ± 13.7 65.8 ± 15.1 0.906
Sex, male (%) 43 (74.1) 38 (66.7) 145 (61.4) 0.180
Epidemiological background
Previous year health-status, QALY 0.78 ± 0.13 0.77 ± 0.14 0.79 ± 0.14 0.973
Obesity 7 (12.1) 4 (7) 12(5) 0.155
COPD 10 (17.2) 12 (21.1) 50 (21.2) 0.815
Asthma 0 (0) 0 (0) 4 (1.7) 1.000
Coronary artery disease 13 (22.4) 15 (26.3) 41 (17.4) 0.265
Heart Failure 15 (25.9) 17 (29.8) 65 (27.5) 0.892
Atrial Fibrillation 8 (13.8) 4 (7) 23 (9.7) 0.472
Arterial Hypertension 14 (24.1) 16 (28.1) 69 (29.3) 0.741
Diabetes Mellitus 9(15.5) 11(19.3) 48 (20.3) 0.699
Chronic Renal Failure 2 (3.4) 3(5.3) 15 (6.3) 0.684
Previous stroke 2 (3.4) 6 (10.5) 19 (8) 0.405
Alcohol abuse 5 (8.6) 3 (5.3) 9 (3.8) 0.261
Admitting etiology
Medical critical illness 37(63.8) 42(73.7) 166(70.3) 0.493
Surgical critical illness 21(36.2) 15(26.3) 70(29.7) 0.493
Cardiac arrest 7(12.1) 8 (14) 13 (5.5) 0.038
Clinical characteristics
APACHE II on admission 21.6 ± 4.5 20.6 ± 6 18.6 ± 7.7 0.006b
Mechanical ventilation 51 (87.9) 50 (87.7) 184 (78) 0.085
Central line placement 54 (93.1) 53 (93) 208 (88.1) 0.364
ARDS 23 (39.7) 14 (24.6) 39 (16.5)  < 0.001
MODS score27 4.3 ± 3.7 1.7 ± 2 1.3 ± 2  < 0.001
Sepsis (without shock) 24 (41.4) 14 (24.6) – 0.047
Septic shock 21 (36.2) 9 (15.8) – 0.013
CRRT 11 (19) 7 (12.3) 14 (5.9) 0.006
Multiple trauma 11 (19) 6 (10.5) 25 (10.6) 0.202
Hemorrhagic Shock 3 (5.2) 3 (5.3) 15 (6.4) 0.918
Colistin administration 52 (89.7) 26 (45.6) –  < 0.001
Glucocorticoid administration 19 (32.8) 12 (21.1) 59 (25) 0.333
  1. Continuous data are presented as means ± SD, categorical data as n (%)
  2. ICU intensive care unit, ABRP antibiotic resistant pathogen, QALY quality-adjusted life years, COPD chronic obstructive pulmonary disease, APACHE II Acute Physiology and Chronic Health Evaluation Score II, ARDS acute respiratory distress syndrome, MODS multiple organ dysfunction syndrome, CRRT continuous renal replacement therapy
  3. aP < 0.05, ABRP versus non-ABRP group
  4. bP < 0.05, ABRP versus no-infection group
  5. cP < 0.05, non-ABRP versus no-infection group (Bonferroni’s post hoc analysis)
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Health and Quality of Life Outcomes

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