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Table 2 Variables related to anesthesia and surgery and uro-oncological features, presented as numbers (%) or median with interquartile range

From: Health-related quality of life and self-reported cognitive function in patients with delayed neurocognitive recovery after radical prostatectomy: a prospective follow-up study

  no DNCR
(n = 235)
DNCR
(n = 64)
Surgical technique   
RARP 107 (45.5) 30 (46.9)
ORP 128 (54.5) 34 (53.1)
Duration of surgery, min 185 (160–210) 193 (163–218)
Estimated blood loss, ml 600 (300–900) 500 (250–900)
Midazolam for premedication 212 (91.4) 61 (95.3)
Anesthetic technique   
Balanced anesthesia 130 (55.3) 31 (48.4)
TIVA 105 (44.7) 33 (51.6)
Additional spinal anesthesia 60 (20.1) 14 (4.7)
Sufentanil, µga 90 (70–100) 90 (65–100)
High vasopressor supportb 196 (83.4) 52 (81.3)
Duration of anesthesia, min 265 (235–290) 270 (237.5–302.5)
Fluids, mlc 2500 (2000–3000) 2500 (2000–3000)
PSA preoperative, ng/ml 7.2 (5.2–11.2) 7.7 (4.8–12.8)
Neoadjuvant androgen deprivation therapy 11 (4.7) 7 (10.9)
Prostate volume (sonographic assessment), ml 36 (28–50) 44 (29–56)
Prostate volume (histopathologic assessment), ml 25 (20–35) 30.1 (20–45)
Tumor volume, ml 4.6 (2.4–8.4) 5.4 (3.1–12.2)
Resected lymph nodes 14 (8–22) 13 (7–21)
N stage   
N0 187 (79.6) 42 (65.6)
N1 31 (13.2) 16 (25.0)
Nx 17 (7.2) 6 (9.4)
T stage   
pT2a-2c 155 (66.0) 32 (50.0)
pT3a-3c 80 (34.0) 32 (50.0)
Gleason scored   
1 15 (6.4) 4 (6.3)
2 144 (61.3) 33 (51.6)
3 52 (22.1) 15 (23.4)
4 2 (0.9) 0 (0.0)
5 22 (9.4) 12 (18.8)
Positive surgical margin   
R0 187 (79.6) 43 (67.2)
R1 48 (20.4) 20 (31.3)
Rx 0 (0.0) 1 (1.6)
  1. DNCR delayed neurocognitive recovery, RARP robot-assisted radical prostatectomy, ORP open retropubic radical prostatectomy, TIVA total-intravenous anesthesia, PSA prostate-specific antigen
  2. aTotal dose administered for anesthesia induction and intraoperatively
  3. bHigh vasopressor support was defined as requirement of noradrenaline > 75% of surgical time
  4. cTotal intraoperative amount
  5. dGrading according to the 2014 International Society of Urological Pathology Consensus Conference