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Table 2 Anxiety or depression symptoms at baseline in association with occurrence of RPL

From: Anxiety and depression are risk factors for recurrent pregnancy loss: a nested case–control study

Symptoms

Total

RPL group (n = 1132)

Control group (n = 1426)

Crude OR (95% CI)

Adjusted OR* (95% CI)

n

%

n

%

Anxiety, SAS

2558

      

 < 50 (normal)

1955

807

71.3

1148

80.5

1.00

1.000

 50–59 (mild)

420

219

19.3

201

14.1

1.23 (1.10–1.37)

1.07 (0.39–1.45)

 60–69 (moderate)

136

80

7.1

56

3.9

1.43 (1.16–1.75)

1.19 (1.01–2.37)

 ≥ 70 (severe)

47

26

2.3

21

1.5

1.31 (0.95–1.81)

1.26 (1.04–2.96)

SAS score (Mean ± SD)

 

42.3 ± 9.7

45.5 ± 10.2

    

Depression, SDS

2558

      

 < 53 (normal)

1419

582

51.4

837

58.7

1.00

1.00

 53–62 (mild)

737

342

30.2

395

27.7

1.10 (1.02–1.19)

1.29 (1.13–4.65)

 63–72 (moderate)

365

186

16.4

179

12.6

1.20 (1.07–1.35)

1.64 (1.02–3.35)

 ≥ 72 (severe)

37

22

1.9

15

1.1

1.46 (0.98–2.16)

1.40 (1.02–2.92)

SDS score (Mean ± SD)

 

49.6 ± 12.0

52.0 ± 11.5

    
  1. Bold values indicate better results than other filtering methods
  2. RPL recurrent pregnancy loss, CI confident interval, OR odds ratio
  3. * adjusted for age, ethnicity, education, family monthly income, active smoking, previous liveborn, and embryonic chromosome abnormalities