Antipsychotics versus no antipsychotics – dichotomous outcomes | ||||||
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Population: children and adolescents with ASD Setting: outpatients and inpatients Intervention: Antipsychotics Comparator: no Antipsychotics | ||||||
Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
Risk with no Antipsychotics | Risk with Antipsychotics | |||||
Serious adverse events | 16 per 1.000 | 17 per 1.000 (8 to 39) | RR 1.07 (0.48 a 2.43) | 1057 (13 RCTs) | ⨁⨁◯◯ LOW a,b | Antipsychotics may increase the risk of severe adverse events slightly |
Adverse events | 657 per 1.000 | 781 per 1.000 (703 to 867) | RR 1.19 (1.07 a 1.32) | 924 (10 RCTs) | ⨁⨁⨁◯ MODERATE c | Antipsychotics probably increase the risk of adverse events |
Dropout due to any cause | 244 per 1.000 | 149 per 1.000 (117 to 190) | RR 0.61 (0.48 a 0.78) | 1124 (15 RCTs) | ⨁⨁⨁◯ MODERATE d | Antipsychotics probably reduce the risk of dropout due to any cause |
Drop-out due to adverse events | 39 per 1.000 | 39 per 1.000 (22 to 70) | RR 0.99 (0.55 to 1.79) | 1010 (12 RCTs) | ⨁⨁◯◯ LOW b,e | Antipsychotics may have little or no effect on the risk of dropouts due to adverse events |