Determinants of health-related quality of life decline in interstitial lung disease

Maqhuzu, Phillen Nozibuyiso; Szentes, Boglarka L.; Kreuter, Michael; Bahmer, Thomas; Kahn, Nicolas; Claussen, Martin; Holle, Rolf; Schwarzkopf, Larissa

doi:10.1186/s12955-020-01570-2

Health and Quality of Life Outcomes

Table 3 Predictors of HRQL deterioration in K-BILD subdomains (weighted)

From: Determinants of health-related quality of life decline in interstitial lung disease

	K-BILD breathlessness and activities			K-BILD chest			K-BILD psychological
	Beta	95% CI	p value	Beta	95% CI	p value	Beta	95% CI	p value
Baseline FVC% predicted	0.006	[− 0.010;0.023]	0.444	0.001	[− 0.015;0.018]	0.863	− 0.021	[− 0.037;− 0.004]	0.014
Baseline DLCO% predicted	− 0.035	[− 0.059;− 0.011]	0.004	− 0.040	[− 0.065;− 0.015]	0.002	− 0.010	[− 0.034;0.015]	0.427
Baseline HRQL score	0.028	[0.011;0.045]	0.001	0.050	[0.033;0.068]	< 0.0001	0.084	[0.051;0.117]	< 0.0001
Age	0.007	[− 0.028;0.042]	0.682	− 0.009	[− 0.049;0.031]	0.665	0.059	[0.016;0.102]	0.007
Time since diagnosis	0.018	[− 0.036;0.073]	0.510	− 0.007	[− 0.067;0.053]	0.821	0.035	[− 0.032;0.101]	0.306
Number of comorbidities	0.113	[− 0.088;0.314]	0.272	0.020	[− 0.193;0.232]	0.856	− 0.091	[− 0.301;0.119]	0.395
Female	0.634	[− 0.037;1.304]	0.064	0.724	[− 0.008;1.456]	0.053	0.332	[− 0.388;1.053]	0.366
ILD subtype (ref = Other ILD)
IPF	0.272	[− 0.551;1.094]	0.518	− 0.192	[− 1.078;0.695]	0.671	− 1.115	[− 2.018;− 0.213]	0.015
Sarcoidosis	− 0.360	[− 1.363;0.643]	0.482	0.814	[− 0.312;1.939]	0.156	− 0.086	[− 1.208;1.036]	0.880
Smoking (ref = non-smoker)
Current smoker	− 1.103	[− 3.201;0.995]	0.303	− 0.582	[− 2.581;1.416]	0.568	0.284	[− 1.734;2.303]	0.783
Former smoker	− 0.308	[− 0.947;0.330]	0.344	− 0.522	[− 1.232;0.188]	0.150	− 0.072	[− 0.798;0.654]	0.845
Immunosuppressant use	0.209	[− 0.554;0.971]	0.592	− 0.183	[− 0.985;0.619]	0.654	− 0.533	[− 1.346;0.280]	0.199
Education (ref = higher)
Basic education	− 0.217	[− 0.945;0.511]	0.559	0.431	[− 0.392;1.253]	0.305	− 0.045	[− 0.834;0.743]	0.910
Secondary education	0.321	[− 0.44;1.082]	0.409	0.811	[− 0.073;1.696]	0.072	0.304	[− 0.556;1.163]	0.489
Unemployed	− 0.443	[− 1.389;0.503]	0.359	0.961	[− 0.117;2.039]	0.080	0.369	[− 0.685;1.423]	0.493
Center 2 (ref = center 1)	0.174	[− 0.553;0.901]	0.639	1.063	[0.252;1.873]	0.010	0.949	[0.125;1.773]	0.024

The figures in italics are results that are statistically significant with p < 0.05

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ISSN: 1477-7525

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