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Table 1 Comparison of patients with HRQL decline and without decline in HRQL

From: Determinants of health-related quality of life decline in interstitial lung disease

 

Worsened HRQL in KBILD total score

Without worsening in HRQL

p value

N

59

135

 

FVC% predicted, mean (SD)

72.4 (21.7)

75.0 (20.9)

0.594

DLCO% predicted, mean (SD)

41.9 (15.8)

45.7 (16.1)

0.058

Baseline K-BILD breathlessness and activities, mean (SD)

48.7 (21.4)

37.9 (20.0)

0.001

K-BILD chest symptoms, mean (SD)

73.5 (23.0)

57.6 (21.3)

 < 0.0001

Baseline K-BILD psychological, mean (SD)

56.4 (15.3)

48.7 (12.6)

0.002

Baseline K-BILD total, mean (SD)

58.2 (12.7)

50.4 (11.1)

0.0002

VAS, mean (SD)a

60.8 (19.0)

59.7 (19.8)

0.743

Mean age, years (SD)

64.5 (12.8)

60.5 (12.4)

0.035

Mean time since diagnosis, years (SD)

3.5 (3.8)

4.6 (7.1)

0.778

Mean number of comorbidities (SD)

3.1 (1.6)

2.8 (1.9)

0.119

Female (%)

16 (27.1)

50 (37.0)

0.180

ILD subtypes

  

0.280

 IPF (%)

17 (28.8)

38 (28.2)

 

 Sarcoidosis (%)

9 (15.3)

34 (25.2)

 

 Other (%)

33 (55.9)

63 (46.7)

 

Smoking status

  

0.929

 Current (%)

2 (3.4)

5 (3.7)

 

 Former (%)

33 (55.9)

79 (58.5)

 

 Immunosuppressant medication use (%)

33 (55.9)

84 (62.2)

0.410

Education

  

0.517

 Basic (%)

24 (40.7)

56 (41.5)

 

 Secondary (%)

20 (33.9)

36 (26.7)

 

 Higher (%)

15 (25.4)

43 (31.9)

 

 Employed (%)

16 (27.1)

43 (31.9)

0.510

 Center 2 (%)

48 (81.4)

77 (57.0)

0.001

  1. aThe complete cases for VAS were 192 and 70 of them had a clinically meaningful decline in HRQL
  2. The figures in italics are results that are statistically significant with p < 0.05