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Table 4 QLQ-H&N35:Quality of life of patients with head and neck cancer during antineoplastic treatment (n = 63)

From: Health-related quality of life became worse in short-term during treatment in head and neck cancer patients: a prospective study

Quality of Life domains T0 T1 T2 p-value ∆T1-T0
n (%)
∆T2-T1
n (%)
∆T2-T0
n (%)
Mean (SD) Median (p25-p75) Mean (SD) Median (p25-p75) Mean (SD) Median (p25-p75) ≥ ± 10 score points n (%)
Speech problems 27.33 (31.54) 11.11 (0.0–55.55) 29.10 (32.08) 33.33 (8.33–58.33) 32.27 (25.68) 25 (0.0–50) 0.139 23 (36.5) 27 (42.9) 26 (41.3)
Social contact 9.62 (14.55) 0.0 (0.0–13.33) 13.75 (20.13) 0.0 (0.0–20) 13.86 (18.67) 6.66 (0.0–20) 0.211 20 (31.7) 14 (22.2) 19 (30.2)
Teeth 11.64 (28.81) 0.0 (0.0–0.0) 14.81 (32.66) 0.0 (0.0–0.0) 13.75 (29.71) 0.0 (0.0–0.0) 0.753 9 (14.3) 8 (12.7) 10 (15.9)
Opening mouth or trismus 18.51 (36.30) 0.0 (0.0–0.0) 22.22 (36.41) 0.0 (0.0–33.33) 28.57 (39.19) 0.0 (0.00–66.66) 0.113 10 (15.9) 13 (20.6) 14 (22.2)
Dry mouth 18.51 (36.30) 0.0 (0.0–0.0) 22.22 (36.41) 0.0 (0.0–33.33) 28.57 (39.19) 0.0 (0.00–66.66) 0.113 10 (15.9) 13 (20.6) 14 (22.2)
Sticky saliva 38.09 (39.19) 33.33 (0.0–66.66) 65.60 (39.24) 66.66 (33.33–100) 65.60 (37.84) 66.66 (33.33–100) < 0.001a 39 (61.9) 16 (25.4) 38 (60.3)
Felt ill 24.86 (37.84) 0.0 (0.0–66.66) 25.92 (37.12) 0.0 (0.0–33.33) 31.21 (39.65) 0.0 (0.00–66.66) 0.147 15 (23.8) 18 (28.6) 9 (14.3)
Pain killers 63.49 (48.53) 100 (0–100) 69.84 (46.26) 100 (0–100) 69.84 (46.26) 100 (0–100) 0.467 9 (14.3) 7 (11.1) 9 (14.3)
Nutritional supplements 25.39 (43.87) 0.0 (0–100) 68.25 (46.92) 100 (0–100) 73.01 (44.74) 100 (0–100) < 0.001a 29 (46.0) 8 (12.7) 31 (49.2)
Feeding tube 6.34 (24.58) 0.0 (0.0–0.0) 22.22 (41.90) 0.0 (0.0–0.0) 23.60 (42.93) 0.0 (0.0–0.0) 0.001 10 (15.9) 4 (6.3) 12 (19.0)
Weight loss 50.79 (50.39) 100 (0.0–100) 53.96 (50.24) 100 (0.0–100) 52.38 (50.34) 100 (0.0–100) 0.924 16 (25.4) 9 (14.3) 14 (22.2)
Weight gain 25.39 (43.87) 0.0 (0.0–100) 31.74 (46.92) 0.0 (0.0–100) 42.85 (49.88) 0.0 (0.0–100) 0.076 14 (22.2) 16 (25.4) 17 (27.0)
  1. P-values followed by letters differed statistically according to the post hoc test at the 5% probability level (Friedman test and Dunn post hoc test ajusted by Bonferroni: a difference between T0 and T1, and T0 and T2. ∆ T1-T0, ∆ T2-T1 and ∆ T2-T0 ≥ 10 or ≤ −10 score points: clinically significant negative difference