Whole group | n | Completers | n | Non-completers | n | |
---|---|---|---|---|---|---|
N = 518 | N = 419 | N = 99 | ||||
Patient characteristics | ||||||
Gender, male (%) | 288 (55.6) | 518 | 232 (55.4) | 419 | 56 (56.6) | 99 |
Age, years | 64.1 ± 9.1 | 518 | 64.3 ± 8.8 | 419 | 63.2 ± 10.3 | 99 |
Current smoker, n (%) | 114 (22.1) | 518 | 79 (18.9) | 419 | 35 (35.4)* | 98 |
Pack years, n | 40.0 (30.0–50.0) | 518 | 40.0 (30.0–50.0) | 403 | 40.0 (30.0–51.0) | 93 |
BMI, kg/m2 | 26.2 ± 5.8 | 518 | 26.2 ± 5.7 | 419 | 26.2 ± 6.3 | 99 |
FFMI, kg/m2 | 17.0 ± 2.5 | 499 | 17.0 ± 2.4 | 405 | 17.0 ± 2.6 | 94 |
FEV1, L | 1.29 ± 0.60 | 518 | 1.30 ± 0.60 | 419 | 1.26 ± 0.60 | 99 |
FEV1% predicted | 48.6 ± 20.0 | 518 | 48.9 ± 20.0 | 419 | 47.3 ± 20.1 | 99 |
FEV1 / FVC, % | 37.5 ± 12.2 | 518 | 37.3 ± 12.1 | 419 | 38.4 ± 12.9 | 99 |
mMRC-score (0/1/2/3/4), % | 2/17/38/25/18 | 512 | 2/17/40/22/18 | 414 | 0/15/27/36/22 | 98 |
GOLD classification (I/II/III/IV), % | 7/36/37/20 | 518 | 8/36/35/21 | 419 | 6/33/43/17 | 99 |
GOLD classification (A/B/C/D), % | 3/20/5/72 | 518 | 2/22/5/71 | 419 | 5/12/5/78 | 99 |
Oxygen saturation, % | 94.6 (92.7–96.0) | 510 | 94.6 (92.8–96.0) | 414 | 94.0 (92.0–96.0) | 96 |
LTOT, n (%) | 125 (24.1) | 518 | 104 (24.8) | 419 | 21 (21.2) | 96 |
Patient-reported outcomes | ||||||
mMRC score, points | 2.4 ± 1.0 | 512 | 2.4 ± 1.0 | 414 | 2.7 ± 1.0 | 98 |
SGRQ-C total score, points | 61.1 ± 17.4 | 504 | 60.1 ± 17.1 | 409 | 65.4 ± 18.1* | 95 |
CAT total score, points | 21.5 ± 6.6 | 505 | 21.5 ± 6.6 | 410 | 21.7 ± 6.9 | 95 |
CCQ total score, points | 2.6 ± 1.0 | 502 | 2.6 ± 1.0 | 409 | 2.8 ± 1.1 | 93 |
HADS-A score, points | 7.8 ± 4.5 | 500 | 7.5 ± 4.4 | 407 | 9.0 ± 4.9* | 93 |
HADS-D score, points | 7.5 ± 4.3 | 500 | 7.4 ± 4.2 | 407 | 8.0 ± 4.9 | 93 |
CDS total score, points | 72.0 (68.0–75.0) | 480 | 69.7 ± 7.2 | 389 | 68.4 ± 7.9 | 91 |
Exercise test outcomes | ||||||
6MWD, meters | 424 ± 124 | 513 | 431 ± 124 | 417 | 393 ± 123* | 96 |
CPET Wmax, W | 70.1 ± 34.2 | 493 | 70.9 ± 33.7 | 407 | 66.6 ± 36.7 | 86 |
CPET VO2peak, ml/min | 1090 ± 414 | 390 | 1094 ± 407 | 316 | 1071 ± 446 | 74 |
CWRT endurance time, seconds | 224 (169–327) | 477 | 235 (174–338) | 392 | 199 (149–294)* | 85 |
TUG test time, seconds | 9.8 (8.5–11.8) | 500 | 9.6 (8.3–11.6) | 408 | 10.2 (8.7–12.7) | 92 |
Quadriceps peak torque, Nm | 94.1 ± 36.4 | 466 | 94.4 ± 35.9 | 383 | 93.5 ± 39.1 | 83 |
Quadriceps total work, J | 1627 ± 741 | 465 | 1641 ± 724 | 382 | 1559 ± 815 | 83 |