Skip to main content
Fig. 1 | Health and Quality of Life Outcomes

Fig. 1

From: Modelling disease course in amyotrophic lateral Sclerosis: pseudo-longitudinal insights from cross-sectional health-related quality of life data

Fig. 1

The D50 model and rD50-derived disease phases. The model yields three key descriptive parameters: D50 as the time taken in months for ALSFRS-score to drop to 24 points, dx as the time constant of ALSFRS-R decay, and the rD50, which describes individual disease course covered in reference to D50. a D50 and dx are calculated from actual ALSFRS-R scores for 3 representative patients with distinct disease profiles; high, moderate, and low disease aggressiveness. b Normalization with rD50 allows for comparability between patients with vastly different disease time scales and shows that patients proceed through similar phases of functional decline independent of individual disease aggressiveness

Back to article page