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Table 4 Quality of life scores before and 6 months after switch from IV or IM HBIG to SC HBIG, stratified by baseline HBIG modality

From: Switch from intravenous or intramuscular to subcutaneous hepatitis B immunoglobulin: effect on quality of life after liver transplantation

 IM HBIGIV HBIG
DomainBaselineEnd of studyP value*BaselineEnd of studyP value*
ITaLi-Q
 Side effects38.1 ± 26.14.5 ± 9.5< 0.00016.9 ± 16.57.6 ± 12.40.48
 Side effects impact16.8 ± 19.32.7 ± 7.5< 0.00013.5 ± 14.91.6 ± 4.70.89
 Negative feelings25.7 ± 27.85.3 ± 10.9< 0.00016.5 ± 11.56.7 ± 10.50.81
 Positive feelings84.9 ± 17.386.6 ± 21.60.2889.6 ± 20.587.9 ± 24.90.64
 Flexibility36.9 ± 27.017.9 ± 14.4< 0.000119.2 ± 17.514.9 ± 16.10.05
 Support55.0 ± 38.529.6 ± 24.8< 0.000146.4 ± 32.437.3 ± 33.00.02
 Need for support51.9 ± 43.27.4 ± 19.0< 0.00019.6 ± 19.28.3 ± 19.40.60
 Satisfaction53.7 ± 21.186.5 ± 16.9< 0.000172.6 ± 18.379.0 ± 16.90.25
SF-36
 Physical functioning75.2 ± 21.676.1 ± 23.50.1878.6 ± 25.482.7 ± 24.80.08
 Role physical62.9 ± 40.774.6 ± 39.20.0269.0 ± 42.376.0 ± 41.80.72
 Pain68.1 ± 24.383.7 ± 23.0< 0.000179.7 ± 23.584.3 ± 23.80.21
 General health45.1 ± 22.245 ± 22.70.6965.9 ± 21.763.1 ± 21.00.31
 Vitality54.1 ± 19.457.1 ± 15.80.0564.6 ± 20.961.9 ± 22.80.83
 Social functioning69.7 ± 22.881.6 ± 22.40.00182.9 ± 20.385.6 ± 17.20.35
 Role emotional58.8 ± 44.075.8 ± 39.80.00283.3 ± 33.084.6 ± 31.60.89
 Mental health63.4 ± 18.765.8 ± 16.30.2271.7 ± 19.669.5 ± 21.20.61
 Physical component summary score44.9 ± 8.047.85 ± 7.20.00747.4 ± 10.449.4 ± 10.10.14
 Mental component summary score44.1 ± 10.147.8 ± 8.9< 0.000150.8 ± 10.549.0 ± 10.70.22
  1. HBIG hepatitis B immunoglobulin, IM intramuscular, ITaLi-Q Immunoglobulin Therapy after Liver transplantation Questionnaire, IV intravenous, SC subcutaneous
  2. * Wilcoxon signed ranks test