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Table 2 General characteristics of the included studies (N = 47)

From: How is the minimal clinically important difference established in health-related quality of life instruments? Review of anchors and methods

Reference (year)DesignPatients, nAge (mean or median)DiseaseHRQOL instrumentMCID estimation method
(n)InstrumentSubscale/
dimension
GenericSpecificAnchor-basedDistribution-based
Oncology
 Kvam AK et al. (2010) [30]Prospective23966Multiple myeloma1EORTC QLQ-C30××
 Kvam AK et al. (2011) [31]Prospective23966Multiple myeloma3EORTC QLQ-C30 EQ-5D 15D××××
 Maringwa J et al. (2011) [32]Randomized / controlled clinical trials94152Brain cancer2QLQ-C30
QLQ-BN20
×××
 Maringwa J et al. (2011) [33]Randomized / controlled clinical trials81257Lung cancer1QLQ-C30×××
 Zeng L et al. (2012) [34]Prospective9363.4Cancer with bone metastases2EORTC QLQ-C30 EORTC QLQ-BM22×××
 Jayadevappa et al. (2012) [35]Prospective60263.3Prostate Cancer2SF-36
ULCA PCI
××××
 Den Oudsten BL et al. (2013) [36]Prospective223 = early stag
383 = benign breast problems
52.9
58.6
Early-stage breast cancer1WHOQOL- 100×××
 Hong F et al. (2013) [37]ProspectiveGroup1 = 191
Group 2 = 436
49
56
Any type of cancer1EORTC QLQ-C30××
 Bedard G et al. (2014) [38]Prospective36957.7Advanced cancer1EORTC QLQ-C30×××
 Binenbaum Y et al. (2014) [39]Prospective101157Oral cavity and Oropharynx Cancer2UW-QOLQ EORTC QLQ-C30××
 Sagberg LM et al. (2014) [40]Prospective16456Intracranial glioma surgery1EQ-5D×××
 Wong E et al. (2015) [41]Prospective9960.6Advanced cancer with brain metastases1EORTC QLQ-BN20×××
 Bedard G et al. (2016) [42]Prospective27665.1Advanced cancer1EORTC QLQ-C15-PAL×××
 Yoshizawa K et al. (2016) [43]Retrospective71066.7Chronic NonCancer Pain1EQ-5D××
 Raman S et al. (2016) [44]Randomized phase III trial20467.5Bone metastases2EORTC QLQ-BM22 EORTC QLQ-C15-PAL×××
 Quinten C et al. (2018) [45]Prospective741 = surgery
683 = chemotherapy
56.18
52.08
Cancer undergoing chemotherapy or surgery1EORTC Global Health Status (GHS)×××
 Kerezoudis P et al. (2018) [46]Prospective125457.4Patients with Vestibular
Schwannoma
1PANQOL×××
Rheumatology/Musculoskeletal
 Soer Rt al (2012) [47]Prospective15151.9Low back pain1EQ-5DCategorical VAS××
 Parker SL et al. (2012) [48]Retrospective47NRSymptomatic pseudoarthrosis2SF-12 EQ-5DSF-12 PCS××
 Parker SL et al. (2012) [49]Retrospective5356.3Revision surgery for same-level recurrent lumbar stenosis-associated back and leg pain2SF-12 EQ-5DSF-12 PCS and MCS××
 Parker SL et al. (2013) [50]Prospective6949.3Anterior cervical discectomy and fusion2SF-12 EQ-5DSF-12 PCS and MCS××
 Chuang LH et al. (2013) [51]Clinical trialGroup1 = 121
Group 2 = 218
A = 45.5
GP = 48.1
Suspected internal derangement of the knee1KQoL-26×××
 Díaz-Arribas MJ et al. (2017) [52]Prospective45846.4Low back pain1SF-12PCS and MCS××
 Shi H et al. (2010) [53]Prospective6770.2Revision total hip arthoplasty1SF-36××
 Solberg T et al. (2013) [54]Prospective69246Lumbar disc herniation1EQ-5D××
 Carreon LY et al. (2013) [55]Prospective722 = primary procedures
333 = revision
60.8
50.9
Primary and revision lumbar fusion surgeries1SF-36PCS××
 Asher AL et al. (2018) [56]Prospective44162Posterior lumbar surgery for grade I degenerative spondylolisthesis1EQ-5D×××
Neurology/Neurovascular
 Kwakkenbos et al. (2013) [57]Prospective211NRSystemic sclerosis2SF-6D EQ-5D××
 Kohn CG et al. (2014) [58]Cross-sectional304456.8Multiple sclerosis1EQ-5D××
 Zhou F et al. (2015) [59]Prospective11357.6Cervical spondylotic myelopathy1SF-36PCS and MCS× ×
 Fulk GD et al. (2010) [60]Prospective3660.9Stroke1SIS-16××
 Frans FA (2014) [61]Prospective12767Critical Limb Ischemia1VascuQol×××
 Kim SK et al. (2015) [62]Prospective48768.3Stroke2SF-6D EQ-5D××
 Chen P et al. (2016) [63]Prospective6552.8Stroke1EQ-5DEQ-5D-5 L×××
 Yuksel S et al. [2018] [64]Prospective185 = surgical patients
86 = nonsurgical patients
52.4
44.9
spinal deformity1SF-36PCS and MCS×××
Psychiatry/Gastroenterology/Dermatology
 Le QA et al. (2013) [65]Randomized, controlled trial20037.5Post-traumatic stress disorder1EQ-5D×××
 Thwin SS et al. (2013) [66]Randomized clinical trials35050.7Schizophrenia1QOLS××
 Falissard B et al. (2015) [67]Randomized35138.6Schizophrenia1QLS××
 Stark RG et al. (2010) [68]Cross-sectional50242Bowel inflammatory disease1EQ-5D××
 Basra MK et al. (2015) [69]Prospective19238.7Inflammatory skin disease1DLQI××
Pediatry
 Modi AC et al. (2011) [70]Cross-sectional26315.1Obesity/weight1IWQOL-kids××
 Newcombe PA et al. (2011) [71]Prospective3426.5 monthsPediatric Chronic Cough1PC-QOL×××
 Hilliard ME et al. (2013) [72]Prospective500412.5Diabetes type 1 and 21PedsQL××
Rhinology
 Gravbrot N et al. (2018) [73]ProspectivePatients undergoing transsphenoidal
surgery
1ASK Nasal-12×××
 Hoehle LP et al. (2018) [74]Prospective20354.1Chronic rhinosinusitis (CRS)1EQ-5DHUV
VAS
×××
Pulmonary
 Akaberi A et al. (2018) [75]Prospective8249.4Pulmonary embolism1PEmbQoL×××
More than one disease
 Alanne S et al. (2015) [76]Prospective49036016 diseases115D××
  1. -: Not used; × used, MCID minimal clinically important difference