Placebo vs Enzalutamid

Improved RIDIT

Chisquare


Week 13

\( {\hat{\pi}}^{} \)

\( {\hat{\pi}}^0 \)

\( {\hat{\pi}}^{+} \)

ARR [95% CI]

Odds ordinal [95% CI]

P_{BH}value

P_{BH}value (a)


Mobility

0.218

0.602

0.181

0.036 [− 0.011; 0.082]

1.12 [0.98; 1.47]

0.254

0.319 (0.319)

Self Care

0.075

0.868

0.057

0.018 [−0.009; 0.045]

1.31 [0.94; 1.83]

0.167

0.450 (0.225)

Usual Activities

0.227

0.592

0.180

0.047 [0.000; 0.094]

1.26 [1.04; 1.53]

0.175

0.204 (0.068)

Pain/Discomfort

0.301

0.487

0.212

0.089 [0.037; 0.142]

1.42 [1.21; 1.67]

0.007

0.025 (0.005)

Anxiety/Depression

0.248

0.579

0.173

0.075 [0.027; 0.122]

1.43 [1.19; 1.71]

0.013

0.024 (0.006)

Week 25

Mobility

0.215

0.597

0.188

0.027 [−0.029; 0.082]

1.14 [0.89; 1.47]

0.257

0.582 (0.582)

Self Care

0.092

0.850

0.058

0.034 [0.001; 0.067]

1.58 [1.11; 2.26]

0.157

0.309 (0.103)

Usual Activities

0.223

0.616

0.161

0.062 [0.008; 0.116]

1.39 [1.10; 1.75]

0.124

0.104 (0.026)

Pain/Discomfort

0.296

0.498

0.206

0.091 [0.029; 0.153]

1.44 [1.19; 1.75]

0.033

0.080 (0.016)

Anxiety/Depression

0.223

0.607

0.170

0.053 [−0.002; 0.108]

1.31 [1.04; 1.66]

0.132

0.322 (0.161)

 CI Confidence Interval, ^{a}Pvalues calculated in [14] using the chisquare test to compare between the placebo and Enzalutamid groups basing on the percentage of patients with (2 or 3) or without (1) problems in each EQ5D dimension. P_{BH}value the BonferroniHolm pvalues correction