Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain

Table 2 Health-related quality of life measures

	Total sample	Gender			Angina Classification					Diagnostic Outcome
		Men	Women	p	Typical Angina Pectoris	Atypical Angina Pectoris	Non-anginal chest discomfort	Other chest discomfort	p^*	ObstructiveCAD	No obstructive CAD	p
SF-12 Physical Health	43.1 (9.3)	44.2 (9.2)	41.8 (9.3)	0.001	41.2 (8.8)^abc	43.3 (9.1)^ade	46.2 (9.0)^bd	46.4 (11.4)^ce	< 0.001	41.9 (8.9)	43.7 (9.4)	0.072
SF-12 Mental Health	45.7 (9.8)	47.0 (9.8)	44.1 (9.7)	< 0.001	44.5 (9.5)^ab	45.1 (9.9)^cd	47.6 (10.1)^ace	51.4 (8.7)^bde	< 0.001	45.6 (10.0)	45.7 (9.8)	0.117
EQ-5D-3 L Visual Analogue Scale	66.3 (18.8)	67.7 (18.3)	64.5 (19.3)	0.010	64.0 (18.1)^ab	65.6 (19.4)^cd	69.6 (18.8)^ace	76.6 (16.8)^bde	< 0.001	64.1 (18.3)	67.2 (19.0)	0.111
EQ-5D-3 L Utility Score	0.69 (0.21)	0.71 (0.20)	0.66 (0.21)	< 0.001	0.65 (0.21)^ab	0.68 (0.20)^cd	0.74 (0.20)^ac	0.79 (0.22)^bd	< 0.001	0.67 (0.20)	0.69 (0.21)	0.230
HADS Depression	5.9 (3.95)	5.5 (3.8)	6.4 (4.1)	< 0.001	6.5 (4.0)^ab	6.1 (3.7)^cd	4.8 (3.8)^ac	4.6 (4.5)^bd	< 0.001	6.0 (4.0)	5.8 (4.0)	0.380
HADS Anxiety	7.5 (4.21)	6.9 (4.0)	8.2 (4.3)	< 0.001	8.3 (4.1)^a	7.5 (4.1)^a	6.5 (4.0)^a	4.6 (4.5)^a	< 0.001	7.3 (4.1)	7.6 (4.2)	0.861

Unadjusted values are presented as mean ± SD. p-values are based upon multiple imputation analyses and adjusted for age and gender where appropriate. Possible site effects were accounted for by mixed model analysis
* Pairwise comparisons: angina classification groups with a common superscript differ significantly (p < 0.05). After applying a Bonferroni correction, some of the comparisons between patients with other or non-anginal chest discomfort and atypical angina pectoris do not reach statistical significance
Measures (possible range in parenthesis): SF-12 Physical and Mental Health (0–100), EQ-5D-3 L Visual Analogue Scale (0–100), EQ-5D-3 L Utility Score (−0.0734–1) and HADS Depression and Anxiety (0–21)

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