Table 3 Summary of Findings (SoF) for the comparison PUFAs versus healthy diet
Summary of findings: | ||||||
|---|---|---|---|---|---|---|
Should polyunsaturated fatty acids versus healthy diet be used for the treatment of children and adolescents with autism spectrum disorder? | ||||||
Patient or population: children and adolescents with autism spectrum disorder | ||||||
Setting: outpatients | ||||||
Intervention: polyunsaturated fatty acids | ||||||
Comparison: healthy diet | ||||||
Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
Risk with healthy diet | Risk with polyunsaturated fatty acids | |||||
Quality of Sleep | – | SMD 1.11 higher (0.21 higher to 2 higher) | – | 23 (1 RCT) | ⨁◯◯◯ VERY LOW a,b | (lower scores indicate improvement) |
Aggression | – | SMD 0 (0.83 lower to 0.82 higher) | – | 23 (1 RCT) | ⨁◯◯◯ VERY LOW a,c | (lower scores indicate improvement) |
Anxiety | – | SMD 0.16 lower (0.99 lower to 0.66 higher) | – | 23 (1 RCT) | ⨁◯◯◯ VERY LOW a,c | (lower scores indicate improvement) |
Attention | – | SMD 0.53 lower (1.37 lower to 0.31 higher) | – | 23 (1 RCT) | ⨁◯◯◯ VERY LOW a,c | (lower scores indicate improvement) |
Social interaction | – | SMD 0.81 lower (1.67 lower to 0.05 higher) | – | 23 (1 RCT) | ⨁◯◯◯ VERY LOW a,c | (lower scores indicate improvement) |
Communication | – | SMD 0.36 higher (0.47 lower to 1.19 higher) | – | 23 (1 RCT) | ⨁◯◯◯ VERY LOW a,c | (lower scores indicate worsening) |