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Table 3 Regression outputs mapped from MSQ (N = 10,977)

From: Longitudinal assessment of utilities in patients with migraine: an analysis of erenumab randomized controlled trials

Utility values mapped from MSQLinear mixed effects model with REMLFractional response model (logit)Fractional response model (probit)Beta regression
Coeff95% CIp valueCoeff95% CIp valueCoeff95% CIp valueCoeff95% CIp value
Erenumab 70 mg (vs placebo)0.006−0.0040.0160.2120.0331−0.0150.8140.1780.020− 0.0890.0480.1760.023−0.0230.0680.335
Erenumab 140 mg (vs placebo)0.0150.0040.0260.0070.07440.0230.1250.0040.0440.01390.0740.0040.0610.0140.1090.011
Baseline MMD0.0017−0.003−0.001<  0.0010.0001− 0.0050.0050.970−0.0004−0.0040.0030.806−0.002−0.0070.0040.557
MMD−0.015−0.016−0.015<  0.001−0.077−0.082− 0.072<  0.001− 0.047− 0.049− 0.044<  0.001− 0.074− 0.079− 0.069< 0.001
Visit
 Week 40.0370.0330.042<  0.0010.1670.1410.193<  0.0010.1010.0860.117<  0.0010.1600.1330.187< 0.001
 Week 80.0380.0330.426<  0.0010.1730.1440.202<  0.0010.1040.0870.122<  0.0010.1640.1340.194< 0.001
 Week 120.0380.0330.042<  0.0010.1760.1450.206<  0.0010.1060.0870.124<  0.0010.1650.1340.197< 0.001
 Week 160.0320.0260.038<  0.0010.1940.1530.235<  0.0010.1150.0910.139<  0.0010.1780.1380.217< 0.001
 Week 200.0300.0240.036<  0.0010.1870.1480.227<  0.0010.1110.0870.134<  0.0010.1700.1330.209< 0.001
 Week 240.0280.0220.035<  0.0010.1850.1440.227<  0.0010.1090.0850.134<  0.0010.1690.1290.209< 0.001
Age0.00040.00020.0008<  0.0010.002−7.11e−060.0040.0510.0010.0000.0020.0440.002−0.0010.0030.074
Female−0.015−0.027− 0.0030.011−0.082−0.140−0.0240.006−0.048−0.082−0.0140.006−0.077−0.130−0.0240.004
Race (vs white)
 Black−0.013−0.0300.0040.140−0.054−0.1390.0320.217− 0.033−0.0830.0180.205−0.050−0.1300.0300.221
 Other−0.022−0.0490.0050.104−0.129−0.2820.0240.099−0.077−0.1680.1350.095−0.109−0.2570.0390.148
RMSE0.1150.1140.1140.114
MAE0.0860.0850.0850.085
  1. Abbreviations: CI confidence interval, Coeff coefficient, MAE mean absolute error, MMD monthly migraine day, MSQ Migraine-Specific Quality of Life Questionnaire, REML restricted maximum likelihood, RMSE root mean squared error