EQ-5D-5L utilities per health states in Spanish population with knee or hip osteoarthritis

García-Pérez, Lidia; Ramos-García, Vanesa; Serrano-Aguilar, Pedro; Pais-Brito, José Luis; Aciego de Mendoza, María; Martín-Fernández, Jesús; García-Maroto, Roberto; Arenaza, Juan Carlos; Bilbao, Amaia

doi:10.1186/s12955-019-1230-x

Health and Quality of Life Outcomes

Table 3 Utility weights (EQ-5D-5 L Index) per subgroup in patients with knee osteoarthritis

From: EQ-5D-5L utilities per health states in Spanish population with knee or hip osteoarthritis

Subgroup		N	Mean	SD	P-value
Age groups (years)	< 45	1			0.746
	45–54.99	17	0.516	0.302
	55–64.99	71	0.540	0.269
	65–74.99	143	0.564	0.279
	75–84.99	143	0.523	0.264
	≥85	18	0.589	0.258
Gender	Women	275	0.528	0.269	0.079
Gender	Men	118	0.581	0.274	0.079
Region	Basque Country	154	0.503	0.570	0.053
	Madrid	158	0.572	0.252
	Canary Islands	81	0.568	0.270
BMI categories	Underweight^a	0	–	–	0.029
	Normal^b	61	0.590	0.214
	Overweight^c	154	0.577	0.261
	Obesity^d	161	0.500	0.299
	Morbid obesity^e	10	0.465	0.215
Joint with osteoarthritis	Right knee	109	0.559	0.261	0.752
	Left knee	117	0.546	0.259
	Both knees	167	0.533	0.287
Time since osteoarthritis diagnosis (years)	<1	62	0.602	0.245	0.188
	1 to < 5	181	0.547	0.269
	5 to < 10	93	0.536	0.270
	10 to < 15	35	0.466	0.307
	≥15	21	0.513	0.297
Contralateral knee	Without prosthesis in the other knee	314	0.546	0.275	0.986
Contralateral knee	With prosthesis in the other knee	78	0.545	0.250	0.986
Other joints	Hip osteoarthritis	53	0.519	0.312	0.101
	No hip osteoarthritis	339	0.549	0.265	0.101
	Osteoarthritis in other joints	228	0.535	0.273	0.813
	No osteoarthritis in other joints	164	0.558	0.269	0.813
Number of comorbidities (Charlson Index)	No comorbidity	215	0.572	0.257	0.149
	1 comorbidity	104	0.523	0.282
	2 comorbidities	40	0.504	0.301
	3 comorbidities	18	0.435	0.279
	≥4 comorbidities	14	0.522	0.282
WOMAC	Pain score 0 to <25^a	42	0.783^bcd	0.187	< 0.0001
	Pain score 25 to < 50^b	163	0.648^acd	0.186
	Pain score 50 to <75^c	139	0.450^abd	0.248
	Pain score 75 to 100^d	48	0.252^abc	0.283
	Stiffness score 0 to <25^a	44	0.716^cd	0.207	< 0.0001
	Stiffness score 25 to < 50^b	134	0.652^cd	0.215
	Stiffness score 50 to <75^c	127	0.506^abd	0.250
	Stiffness score 75 to 100^d	87	0.347^abc	0.277
	Physical function score 0 to <25^a	41	0.845^bcd	0.113	< 0.0001
	Physical function score 25 to <50^b	146	0.664^acd	0.173
	Physical function score 50 to <75^c	143	0.475^abd	0.205
	Physical function score 75 to 100^d	63	0.230^abc	0.293
	WOMAC Score 0 to <25^a	44	0.829^bcd	0.117	< 0.0001
	WOMAC Score 25 to <50^b	145	0.665^acd	0.172
	WOMAC Score 50 to <75^c	143	0.464^abd	0.220
	WOMAC Score 75 to 100^d	50	0.189^abc	0.277
Oxford Knee Score (OKS)	Severe (0–19)^a	168	0.346^bcd	0.255	< 0.0001
	Moderate to severe (20–29)^b	128	0.609^acd	0.157
	Mild to moderate (30–39)^c	74	0.780^abd	0.109
	Satisfactory joint function (40–48)^d	21	0.879^abc	0.097
Non-surgery treatments	No pharmacologic treatment	53	0.579	0.299	0.321
	Any pharmacologic treatment	340	0.539	0.267	0.321
	Symptomatic slow acting drugs for osteoarthritis (SYSADOA)	50	0.564	0.247	0.567*
	Non-opioid pain medication	242	0.546	0.263	0.919*
	Nonsteroidal anti-inflammatory drugs (NSAID)	152	0.529	0.283	0.529*
	Opiate derivatives	96	0.538	0.274	0.836*
	Opioid pain medication	21	0.333	0.309	0.005*
	Rehabilitation / Physiotherapy	14	0.559	0.295	0.854*
Knee replacement	Waiting for prosthesis	92	0.400	0.266	< 0.0001**
	Prosthesis in the last 6 months	65	0.683	0.243	< 0.0001**
	Complication after prosthesis	2	0.424	0.007	–

BMI Body mass index, SD Standard deviation, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index
p-values represents the significance of differences between groups by means of ANOVA except for (*) P-value comparing with the whole sample’s utility value (0.544) (one sample t-test), and (**) P-value comparing sample before and after (6 months) the prosthesis (paired sample t-test)
Superscript letters indicate differences among the subgroups according to Tamhane’s T2 post hoc test for multiple comparisons at P-value< 0.01

Back to article page

ISSN: 1477-7525

Contact us

Submission enquiries: journalsubmissions@springernature.com