Table 4 Cutoff values of the Angioedema Quality of Life (AE-QoL) questionnaire that differentiate patients with “no effect” from patients with “moderate to large effect” on health-related quality of life (HRQoL) using the Patient Global Assessment Quality of Life (PGA-QoL) and the Dermatology Life Quality Index (DLQI)
From: Angioedema quality of life questionnaire (AE-QoL) - interpretability and sensitivity to change
Patients with no effect on HRQoL using: | ||||||
PGA-QoL score of 0 | DLQI score of 0–1 | |||||
AE-QoL score | Sensitivity (%) | Specificity (%) | Accuracy (%) | Sensitivity (%) | Specificity (%) | Accuracy (%) |
22 | 85.7% | 80.4% | 82.6% | 78.8% | 73.6% | 75.6% |
23 | 88.6% | 80.4% | 83.7% | 81.8% | 73.6% | 76.7% |
24 | 88.6% | 78.4% | 82.6% | 84.8% | 73.6% | 77.9% |
25 | 88.6% | 78.4% | 82.6% | 84.8% | 73.6% | 77.9% |
26 | 88.6% | 74.5% | 80.2% | 87.9% | 71.7% | 77.9% |
AUC | 0.88 (0.80–0.96) | 0.85 (0.77–0.94) | ||||
Patients with moderate to large effect on HRQoL using: | ||||||
PGA-QoL score of 2–4 | DLQI score of 6–30 | |||||
AE-QoL score | Sensitivity (%) | Specificity (%) | Accuracy (%) | Sensitivity (%) | Specificity (%) | Accuracy (%) |
35 | 78.8 | 75.0% | 77.9% | 89.1% | 74.2% | 83.7% |
36 | 78.8 | 75.0% | 77.9% | 89.1% | 74.2% | 83.7% |
37 | 81.8 | 75.0% | 80.2% | 90.9% | 71.0% | 83.7% |
38 | 81.8 | 75.0% | 80.2% | 90.9% | 71.0% | 83.7% |
39 | 87.9 | 65.0% | 82.6% | 92.7% | 54.8% | 79.1% |
AUC | 0.87 (0.78–0.95) | 0.86 (0.77–0.95) | ||||