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Table 4 Cutoff values of the Angioedema Quality of Life (AE-QoL) questionnaire that differentiate patients with “no effect” from patients with “moderate to large effect” on health-related quality of life (HRQoL) using the Patient Global Assessment Quality of Life (PGA-QoL) and the Dermatology Life Quality Index (DLQI)

From: Angioedema quality of life questionnaire (AE-QoL) - interpretability and sensitivity to change

Patients with no effect on HRQoL using:
  PGA-QoL score of 0 DLQI score of 0–1
AE-QoL score Sensitivity (%) Specificity (%) Accuracy (%) Sensitivity (%) Specificity (%) Accuracy (%)
22 85.7% 80.4% 82.6% 78.8% 73.6% 75.6%
23 88.6% 80.4% 83.7% 81.8% 73.6% 76.7%
24 88.6% 78.4% 82.6% 84.8% 73.6% 77.9%
25 88.6% 78.4% 82.6% 84.8% 73.6% 77.9%
26 88.6% 74.5% 80.2% 87.9% 71.7% 77.9%
AUC 0.88 (0.80–0.96) 0.85 (0.77–0.94)
Patients with moderate to large effect on HRQoL using:
  PGA-QoL score of 2–4 DLQI score of 6–30
AE-QoL score Sensitivity (%) Specificity (%) Accuracy (%) Sensitivity (%) Specificity (%) Accuracy (%)
35 78.8 75.0% 77.9% 89.1% 74.2% 83.7%
36 78.8 75.0% 77.9% 89.1% 74.2% 83.7%
37 81.8 75.0% 80.2% 90.9% 71.0% 83.7%
38 81.8 75.0% 80.2% 90.9% 71.0% 83.7%
39 87.9 65.0% 82.6% 92.7% 54.8% 79.1%
AUC 0.87 (0.78–0.95) 0.86 (0.77–0.95)
  1. Abbreviation: AUC, Area under the curve Bold entries indicate the most important results as discussed in the text