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Table 3 Changes in AE-QoL total score to identify “improvement” (decrease in PGA-QoL score of ≥1) and “worsening/stable” (increased or unchanged PGA-QoL score)

From: Angioedema quality of life questionnaire (AE-QoL) - interpretability and sensitivity to change

Changes in AE-QoL total score Sensitivity (%) (patients correctly classified as worsening/stable) Specificity (%) (patients correctly classified as improvement) Accuracy (%) (proportion of correctly classified patients)
5 64.3% 76.7% 68.6%
6 73.2% 76.7% 74.4%
7 73.2% 76.7% 74.4%
8 75.0% 70.0% 73.3%
9 78.6% 70.0% 75.6%
10 78.6% 70.0% 75.6%
AUC 0.81 (0.72–0.91)
  1. Abbreviations: AE-QoL, Angioedema quality of life; PGA-QoL, Patient global assessment quality of life; AUC, Area under the curve