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Table 3 Changes in AE-QoL total score to identify “improvement” (decrease in PGA-QoL score of ≥1) and “worsening/stable” (increased or unchanged PGA-QoL score)

From: Angioedema quality of life questionnaire (AE-QoL) - interpretability and sensitivity to change

Changes in AE-QoL total score

Sensitivity (%) (patients correctly classified as worsening/stable)

Specificity (%) (patients correctly classified as improvement)

Accuracy (%) (proportion of correctly classified patients)

5

64.3%

76.7%

68.6%

6

73.2%

76.7%

74.4%

7

73.2%

76.7%

74.4%

8

75.0%

70.0%

73.3%

9

78.6%

70.0%

75.6%

10

78.6%

70.0%

75.6%

AUC

0.81 (0.72–0.91)

  1. Abbreviations: AE-QoL, Angioedema quality of life; PGA-QoL, Patient global assessment quality of life; AUC, Area under the curve