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Table 2 Treatment patterns of SCD patients prescribed HU

From: Treatment patterns and economic burden of sickle-cell disease patients prescribed hydroxyurea: a retrospective claims-based study

Outcomes SCD patients prescribed HU therapy
(N = 3999)
N/Mean %/SD
HU Dose
 HU index dose (mg) 980.63 656.62
 Dosing modification −3.85 468.16
SCD Management (during the first 12 months)
 Blood transfusions
  # of Patients 1523 38.1%
  Number of blood transfusions 1.11 2.28
 Transcranial Doppler ultrasonography 1001 25.0%
 Pneumococcal vaccine 175 4.4%
 Meningococcal vaccine 115 2.9%
 Bone marrow transplant 11 0.3%
Monitoring Patterns (during a 12-month period)
 Chest X-ray 2784 69.6%
 X-ray of extremity 839 21.0%
 Abdominal plain film 586 14.7%
 Computerized tomography 341 8.5%
 Nuclear medicine studies 158 4.0%
 Echocardiography 1239 31.0%
 Electrocardiogram 1444 36.1%
 Eye exams 909 22.7%
 Complete blood count 2945 73.6%
 Iron tests 1167 29.2%
  1. SCD sickle cell disease, HU hydroxyurea, SD standard deviation