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Table 2 Treatment patterns of SCD patients prescribed HU

From: Treatment patterns and economic burden of sickle-cell disease patients prescribed hydroxyurea: a retrospective claims-based study

Outcomes

SCD patients prescribed HU therapy

(N = 3999)

N/Mean

%/SD

HU Dose

 HU index dose (mg)

980.63

656.62

 Dosing modification

−3.85

468.16

SCD Management (during the first 12 months)

 Blood transfusions

  # of Patients

1523

38.1%

  Number of blood transfusions

1.11

2.28

 Transcranial Doppler ultrasonography

1001

25.0%

 Pneumococcal vaccine

175

4.4%

 Meningococcal vaccine

115

2.9%

 Bone marrow transplant

11

0.3%

Monitoring Patterns (during a 12-month period)

 Chest X-ray

2784

69.6%

 X-ray of extremity

839

21.0%

 Abdominal plain film

586

14.7%

 Computerized tomography

341

8.5%

 Nuclear medicine studies

158

4.0%

 Echocardiography

1239

31.0%

 Electrocardiogram

1444

36.1%

 Eye exams

909

22.7%

 Complete blood count

2945

73.6%

 Iron tests

1167

29.2%

  1. SCD sickle cell disease, HU hydroxyurea, SD standard deviation