Health and Quality of Life Outcomes

Table 6 Models mapping from FSS total to PBMs using validation dataset

From: Using the Fatigue Severity Scale to inform healthcare decision-making in multiple sclerosis: mapping to three quality-adjusted life-year measures (EQ-5D-3L, SF-6D, MSIS-8D)

	EQ-5D				SF-6D						MSIS-8D
	CLAD A		CLAD C		OLS A		CLAD A		CLAD C		CLAD A		CLAD C
	Coeff	SE	Coeff	SE	Coeff	SE	Coeff	SE	Coeff	SE	Coeff	SE	Coeff	SE
FSS total	−0.007*	0.0012	−0.008*	0.0011	−0.004*	0.0005	−0.004*	0.0007	−0.004*	0.0008	−0.006*	0.0010	−0.006*	0.0011
Age			−0.004*	0.0011					0.0004	0.0009			−0.001	0.0020
Female			−0.009	0.0260					0.002	0.0187			0.012	0.0395
Constant	1.001	0.0549	1.233	0.0979	0.81	0.0261	0.793	0.0394	0.827	0.0781	0.939	0.0432	0.974	0.1252
Observations	260		258		152		152		152		157		157
F statistic					54.71								0.185
Prob>F					< 0.0001
R-squared					0.316
Pseudo R2	0.119		0.141				0.169		0.169		0.180		0.185
Coefficients	1		3		1		1		3		1		3
Significant coefficients	1		2		1		1		1		1		1
Mean absolute error (MAE)	0.183		0.179		0.068		0.068		0.071		0.118		0.114
Mean squared error (MSE)	0.076		0.071		0.008		0.008		0.009		0.023		0.022
Root MSE	0.276		0.267		0.09		0.09		0.095		0.151		0.149
Normalised root MSE	17.31%		16.75%		12.88%		12.88%		13.59%		18.80%		18.56%
Individuals with MAE < 0.25	78.85%		76.92%		98.68%		98.03%		98.03%		92.36%		91.08%
Individuals with MAE < 0.1	49.62%		47.31%		76.32%		75.00%		75.66%		50.32%		52.23%
Individuals with MAE < 0.05	24.62%		25.77%		48.68%		46.05%		46.05%		22.93%		31.21%

Coeff model coefficient, SE standard error, CLAD Censored Least Adjusted Deviation model, EQ-5D EuroQoL EQ-5D-3L; SF-6D Short-Form 6D; MSIS-8D Multiple Sclerosis Impact Scale – Eight Dimensions
*p < 0.001

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