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Table 2 Comparison of measures against conceptual framework

From: Using the Fatigue Severity Scale to inform healthcare decision-making in multiple sclerosis: mapping to three quality-adjusted life-year measures (EQ-5D-3L, SF-6D, MSIS-8D)

Conceptual framework

Fatigue severity scale

EQ-5D

SF-6D

MSIS-8D

Descriptions of fatigue

 General fatigue or vitality

3. Easily fatigued

5. Causes frequent problems

8. Among most disabling symptoms

6. Vitality

Physical effects

 General

4. Interferes with physical functioning

6. Prevents sustained physical functioning

1. Physical functioning

1. Physically demanding tasks

Triggers-

 Specific physical effects

2. Exercise brings on fatigue

4. Pain/Discomfort

1. Mobility

4. Pain

3. Being stuck at home

Mental effects

 General

5. Feeling mentally fatigued

 Specific psychological effects

1. Motivation is lower

5. Anxiety/Depression

5. Mental health

6. Irritable, impatient, short-tempered

8. Feeling depressed

 Specific cognitive effects

7. Problems concentrating

 Indirect effects

Participation effects

 General

7. Interferes with duties & responsibilities

9. Interferes with work, family, social life

 

3. Being stuck at home

 Effects on specific activities

 

2. Self-Care

3. Usual Activities

1. Physical functioning

2. Role limitations

3. Social functioning

4. Pain

2. Social and leisure activities

4. Work or other daily activities

  1. EQ-5D EuroQoL EQ-5D-3L; SF-6D Short-Form 6D, MSIS-8D Multiple Sclerosis Impact Scale – Eight Dimensions
  2. Explanation for allocation of particular items:
  3. • SF-6D Physical functioning: included under both “Physical effects” and “Functioning/ participation” because level descriptions include “moderate/ vigorous activities” and “bathing and dressing”
  4. • SF-6D Pain: included under both “Physical effects” and “Functioning/ participation” because level descriptions include “pain that interferes with your normal work”
  5. • SF-6D Mental health: included under “Specific psychological effects” because level descriptions refer to feeling “tense or downhearted and low”
  6. • SF-6D Role limitations: included under “Functioning/ participation – activities” because level descriptions refer to “work or other regular daily activities”.
  7. • MSIS-8D Being stuck at home: included under “Specific physical effects” because the MSIS-8D uses this question as a proxy for mobility, however we have also included it here under “Functioning/ participation”