Fatigue level changes with time in long-term Hodgkin and non-Hodgkin lymphoma survivors: a joint EORTC-LYSA cross-sectional study

Busson, Raphaël; van der Kaaij, Marleen; Mounier, Nicolas; Aleman, Berthe M. P.; Thiéblemont, Catherine; Stamatoullas, Aspasia; Ribrag, Vincent; Tilly, Hervé; Haioun, Corinne; Casasnovas, René-Olivier; Kluin-Nelemans, Hanneke C.; Henry-Amar, Michel

doi:10.1186/s12955-019-1186-x

Table 3 Multiple linear regression models on long-term fatigue using MFI assessment

From: Fatigue level changes with time in long-term Hodgkin and non-Hodgkin lymphoma survivors: a joint EORTC-LYSA cross-sectional study

			Hodgkin lymphoma		Non-Hodgkin lymphomas
			Coef β (sd)	P-value	Coef β (sd)	P-value
General fatigue	Reference score (intercept)		23.7 (1.9)	< 0.001	32.0 (2.9)	< 0.001
	Age at time of fatigue assessment
	per 10-yr increase	20–69 yrs	1.3 (0.6)	0.047	−1.2 (0.7)	0.089
	per 10-yr increase	≥ 70 yrs	5.0 (5.1)	0.328	9.5 (1.7)	< 0.001
	Years since treatment start
	per 10-yr increase		1.9 (0.8)	0.018	−1.3 (1.0)	0.194
	Gender	Male	0.0		0.0
	Gender	Female	7.1 (1.2)	< 0.001	5.2 (1.3)	< 0.001
	Education level ^a	High	0.0		0.0
	Education level ^a	Low	3.5 (1.4)	0.015	1.6 (1.4)	0.240
	Cohabitation status
	living with partner	Yes	0.0		0.0
	living with partner	No	4.7 (1.6)	0.003	1.4 (1.4)	0.322
	Obesity ^b	No	0.0		0.0
	Obesity ^b	Yes	7.6 (2.0)	< 0.001	5.8 (1.7)	0.001
	Health disorders	No	0.0		0.0
	Health disorders	Yes	14.6 (1.3)	< 0.001	15.6 (1.3)	< 0.001
Physical Fatigue	Reference score (intercept)		13.3 (1.9)	< 0.001	27.4 (3.0)	< 0.001
	Age at time of fatigue assessment		13.3 (1.9)	< 0.001	27.4 (3.0)	< 0.001
	per 10-yr increase	20–69 yrs	2.3 (0.6)	0.001	−1.6 (0.7)	0.033
	per 10-yr increase	≥ 70 yrs	10.1 (5.0)	0.045	12.2 (1.7)	< 0.001
	Years since treatment start
	per 10-yr increase		3.7 (0.8)	< 0.001	−1.0 (1.0)	0.328
	Gender	Male	0.0		0.0
	Gender	Female	5.2 (1.2)	< 0.001	2.8 (1.3)	0.034
	Education level ^a	High	0.0		0.0
	Education level ^a	Low	3.5 (1.4)	0.012	2.6 (1.4)	0.074
	Cohabitation status
	living with partner	Yes	0.0		0.0
	living with partner	No	4.8 (1.6)	0.002	2.2 (1.5)	0.150
	Obesity ^b	No	0.0		0.0
	Obesity ^b	Yes	10.3 (1.9)	< 0.001	6.9 (1.8)	< 0.001
	Health disorders	No	0.0		0.0
	Health disorders	Yes	14.7 (1.3)	< 0.001	15.6 (3.0)	< 0.001
Reduced activity	Reference score (intercept)		11.4 (1.7)	< 0.001	17.3 (2.6)	< 0.001
	Age at time of fatigue assessment
	per 10-yr increase	20–69 yrs	3.4 (0.6)	< 0.001	1.6 (0.6)	0.011
	per 10-yr increase	≥ 70 yrs	12.8 (4.6)	0.005	11.3 (1.5)	< 0.001
	Years since treatment start
	per 10-yr increase		1.6 (0.7)	0.025	−1.0 (0.9)	0.273
	Gender	Male	0.0		0.0
	Gender	Female	−0.4 (1.1)	0.723	−0.6 (1.2)	0.611
	Education level ^a	High	0.0		0.0
	Education level ^a	Low	4.2 (1.3)	0.001	2.2 (1.3)	0.074
	Cohabitation status
	living with partner	Yes	0.0		0.0
	living with partner	No	7.9 (1.4)	< 0.001	3.2 (1.3)	0.015
	Obesity ^b	No	0.0		0.0
	Obesity ^b	Yes	5.6 (1.7)	0.001	5.2 (1.5)	0.001
	Health disorders	No	0.0		0.0
	Health disorders	Yes	9.2 (1.2)	< 0.001	8.9 (1.2)	< 0.001
Reduced motivation	Reference score (intercept)		7.4 (1.6)	< 0.001	12.6 (2.6)	< 0.001
	Age at time of fatigue assessment
	per 10-yr increase	20–69 yrs	3.7 (0.5)	< 0.001	0.8 (0.6)	0.212
	per 10-yr increase	≥ 70 yrs	12.7 (4.2)	0.003	10.3 (1.5)	< 0.001
	Years since treatment start
	per 10-yr increase		1.5 (0.7)	0.022	−0.5 (0.9)	0.582
	Gender	Male	0.0		0.0
	Gender	Female	0.4 (1.0)	0.692	2.6 (1.1)	0.020
	Education level ^a	High	0.0		0.0
	Education level ^a	Low	4.0 (1.2)	0.001	3.4 (1.2)	0.005
	Cohabitation status
	living with partner	Yes	0.0		0.0
	living with partner	No	6.0 (1.3)	< 0.001	4.7 (1.3)	< 0.001
	Obesity ^b	No	0.0		0.0
	Obesity ^b	Yes	7.1 (1.6)	< 0.001	4.0 (1.5)	0.008
	Health disorders	No	0.0		0.0
	Health disorders	Yes	6.5 (1.1)	< 0.001	8.4 (1.2)	< 0.001
Mental fatigue	Reference score (intercept)		19.3 (1.8)	< 0.001	21.4 (2.9)	0.002
	Age at time of fatigue assessment
	per 10-yr increase	20–69 yrs	0.6 (0.6)	0.318	−0.9 (0.7)	0.211
	per 10-yr increase	≥ 70 yrs	−0.2 (4.9)	0.965	3.4 (1.7)	0.043
	Years since treatment start
	per 10-yr increase		−0.6 (0.8)	0.431	−0.2 (1.0)	0.866
	Gender	Male	0.0		0.0
	Gender	Female	3.4 (1.2)	0.005	1.4 (1.3)	0.282
	Education level ^a	High	0.0		0.0
	Education level ^a	Low	4.7 (1.4)	0.001	4.2 (1.4)	0.002
	Cohabitation status
	living with partner	Yes	0.0		0.0
	living with partner	No	4.4 (1.5)	0.003	4.0 (1.4)	0.006
	Obesity ^b	No	0.0		0.0
	Obesity ^b	Yes	2.6 (1.9)	0.159	−0.1 (1.7)	0.929
	Health disorders	No	0.0		0.0
	Health disorders	Yes	10.7 (1.3)	< 0.001	10.2 (1.3)	< 0.001

sd indicates standard deviation
^aHigh education level indicates university or high school; low education level indicates college, elementary school or level unspecified
^bObesity indicates Body Mass Index (BMI) ≥ 30 kg/m²

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