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Table 3 Multiple linear regression models on long-term fatigue using MFI assessment

From: Fatigue level changes with time in long-term Hodgkin and non-Hodgkin lymphoma survivors: a joint EORTC-LYSA cross-sectional study

   Hodgkin lymphoma Non-Hodgkin lymphomas
Coef β (sd) P-value Coef β (sd) P-value
General fatigue Reference score (intercept) 23.7 (1.9) <  0.001 32.0 (2.9) <  0.001
Age at time of fatigue assessment
per 10-yr increase 20–69 yrs 1.3 (0.6) 0.047 −1.2 (0.7) 0.089
≥ 70 yrs 5.0 (5.1) 0.328 9.5 (1.7) <  0.001
Years since treatment start
per 10-yr increase 1.9 (0.8) 0.018 −1.3 (1.0) 0.194
Gender Male 0.0   0.0  
Female 7.1 (1.2) <  0.001 5.2 (1.3) <  0.001
Education level a High 0.0   0.0  
Low 3.5 (1.4) 0.015 1.6 (1.4) 0.240
Cohabitation status
living with partner Yes 0.0   0.0  
No 4.7 (1.6) 0.003 1.4 (1.4) 0.322
Obesity b No 0.0   0.0  
Yes 7.6 (2.0) <  0.001 5.8 (1.7) 0.001
Health disorders No 0.0   0.0  
Yes 14.6 (1.3) <  0.001 15.6 (1.3) <  0.001
Physical Fatigue Reference score (intercept) 13.3 (1.9) <  0.001 27.4 (3.0) <  0.001
Age at time of fatigue assessment
per 10-yr increase 20–69 yrs 2.3 (0.6) 0.001 −1.6 (0.7) 0.033
≥ 70 yrs 10.1 (5.0) 0.045 12.2 (1.7) <  0.001
Years since treatment start
per 10-yr increase 3.7 (0.8) <  0.001 −1.0 (1.0) 0.328
Gender Male 0.0   0.0  
Female 5.2 (1.2) <  0.001 2.8 (1.3) 0.034
Education level a High 0.0   0.0  
Low 3.5 (1.4) 0.012 2.6 (1.4) 0.074
Cohabitation status
living with partner Yes 0.0   0.0  
No 4.8 (1.6) 0.002 2.2 (1.5) 0.150
Obesity b No 0.0   0.0  
Yes 10.3 (1.9) <  0.001 6.9 (1.8) <  0.001
Health disorders No 0.0   0.0  
Yes 14.7 (1.3) <  0.001 15.6 (3.0) <  0.001
Reduced activity Reference score (intercept) 11.4 (1.7) <  0.001 17.3 (2.6) <  0.001
Age at time of fatigue assessment
per 10-yr increase 20–69 yrs 3.4 (0.6) <  0.001 1.6 (0.6) 0.011
≥ 70 yrs 12.8 (4.6) 0.005 11.3 (1.5) <  0.001
Years since treatment start
per 10-yr increase 1.6 (0.7) 0.025 −1.0 (0.9) 0.273
Gender Male 0.0   0.0  
Female −0.4 (1.1) 0.723 −0.6 (1.2) 0.611
Education level a High 0.0   0.0  
Low 4.2 (1.3) 0.001 2.2 (1.3) 0.074
Cohabitation status
living with partner Yes 0.0   0.0  
No 7.9 (1.4) <  0.001 3.2 (1.3) 0.015
Obesity b No 0.0   0.0  
Yes 5.6 (1.7) 0.001 5.2 (1.5) 0.001
Health disorders No 0.0   0.0  
Yes 9.2 (1.2) <  0.001 8.9 (1.2) <  0.001
Reduced motivation Reference score (intercept) 7.4 (1.6) <  0.001 12.6 (2.6) <  0.001
Age at time of fatigue assessment
per 10-yr increase 20–69 yrs 3.7 (0.5) <  0.001 0.8 (0.6) 0.212
≥ 70 yrs 12.7 (4.2) 0.003 10.3 (1.5) <  0.001
Years since treatment start
per 10-yr increase 1.5 (0.7) 0.022 −0.5 (0.9) 0.582
Gender Male 0.0   0.0  
Female 0.4 (1.0) 0.692 2.6 (1.1) 0.020
Education level a High 0.0   0.0  
Low 4.0 (1.2) 0.001 3.4 (1.2) 0.005
Cohabitation status
living with partner Yes 0.0   0.0  
No 6.0 (1.3) < 0.001 4.7 (1.3) <  0.001
Obesity b No 0.0   0.0  
Yes 7.1 (1.6) < 0.001 4.0 (1.5) 0.008
Health disorders No 0.0   0.0  
Yes 6.5 (1.1) <  0.001 8.4 (1.2) <  0.001
Mental fatigue Reference score (intercept)   19.3 (1.8) <  0.001 21.4 (2.9) 0.002
Age at time of fatigue assessment
per 10-yr increase 20–69 yrs 0.6 (0.6) 0.318 −0.9 (0.7) 0.211
≥ 70 yrs −0.2 (4.9) 0.965 3.4 (1.7) 0.043
Years since treatment start
per 10-yr increase −0.6 (0.8) 0.431 −0.2 (1.0) 0.866
Gender Male 0.0   0.0  
Female 3.4 (1.2) 0.005 1.4 (1.3) 0.282
Education level a High 0.0   0.0  
Low 4.7 (1.4) 0.001 4.2 (1.4) 0.002
Cohabitation status
living with partner Yes 0.0   0.0  
No 4.4 (1.5) 0.003 4.0 (1.4) 0.006
Obesity b No 0.0   0.0  
Yes 2.6 (1.9) 0.159 −0.1 (1.7) 0.929
Health disorders No 0.0   0.0  
Yes 10.7 (1.3) <  0.001 10.2 (1.3) <  0.001
  1. sd indicates standard deviation
  2. aHigh education level indicates university or high school; low education level indicates college, elementary school or level unspecified
  3. bObesity indicates Body Mass Index (BMI) ≥ 30 kg/m2
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