Clostridium difficile Infection–Daily Symptoms (CDI-DaySyms™) questionnaire: psychometric characteristics and responder thresholds

Table 3 Construct validity (convergent and divergent validity): correlation between CDI-DaySyms™ PRO questionnaire symptoms and other PROs

	N	CDI-DaySyms™ symptoms^a at baseline
	N	Diarrhea symptoms	Abdominal symptoms	Systemic/Other symptoms
GSRS
Abdominal pain	158	0.21*	0.46***	0.39***
Reflux	158	0.27**	0.31***	0.40***
Indigestion	158	0.13	0.39***	0.22*
Diarrhea	158	0.39***	0.27**	0.22*
Constipation	157	0.09	0.16	0.17*
ADL questionnaire–total score	157	0.17*	0.25*	0.38***
Patient-reported overall health scale
Self-rated health (item 1)	156	−0.12	0.08	−0.13
Overall quality of life (item 2)	155	−0.05	0.07	−0.12
Rating of physical health (item 3)	157	−0.14	0.08	−0.17*
Mental health (item 4)	157	−0.01	0.15	−0.13
Global rating of pain (item 5)	156	0.26*	0.52***	0.31***
Fatigue (item 6)	156	0.27**	0.26*	0.53***
PGA-S scale	159	0.43***	0.36***	0.28**
CGI-S scale	167	0.25**	0.29**	0.22*

ADL activities of daily living, CDI Clostridium difficile infection, CDI-DaySyms™ Clostridium difficile infection–daily symptoms, CGI-S clinical global impression of severity, GSRS gastrointestinal symptom rating scale, PGA-S patient global assessment of severity, PRO patient-reported outcome
^aPearson product moment correlations or Spearman-rank correlations
*p < 0.05; **p < 0.001; ***p < 0.0001

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