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Table 3 Construct validity (convergent and divergent validity): correlation between CDI-DaySyms™ PRO questionnaire symptoms and other PROs

From: Clostridium difficile Infection–Daily Symptoms (CDI-DaySyms™) questionnaire: psychometric characteristics and responder thresholds

  N CDI-DaySyms™ symptomsa at baseline
Diarrhea symptoms Abdominal symptoms Systemic/Other symptoms
GSRS
 Abdominal pain 158 0.21* 0.46*** 0.39***
 Reflux 158 0.27** 0.31*** 0.40***
 Indigestion 158 0.13 0.39*** 0.22*
 Diarrhea 158 0.39*** 0.27** 0.22*
 Constipation 157 0.09 0.16 0.17*
ADL questionnaire–total score 157 0.17* 0.25* 0.38***
Patient-reported overall health scale
 Self-rated health (item 1) 156 −0.12 0.08 −0.13
 Overall quality of life (item 2) 155 −0.05 0.07 −0.12
 Rating of physical health (item 3) 157 −0.14 0.08 −0.17*
 Mental health (item 4) 157 −0.01 0.15 −0.13
 Global rating of pain (item 5) 156 0.26* 0.52*** 0.31***
 Fatigue (item 6) 156 0.27** 0.26* 0.53***
PGA-S scale 159 0.43*** 0.36*** 0.28**
CGI-S scale 167 0.25** 0.29** 0.22*
  1. ADL activities of daily living, CDI Clostridium difficile infection, CDI-DaySyms™ Clostridium difficile infection–daily symptoms, CGI-S clinical global impression of severity, GSRS gastrointestinal symptom rating scale, PGA-S patient global assessment of severity, PRO patient-reported outcome
  2. aPearson product moment correlations or Spearman-rank correlations
  3. *p < 0.05; **p < 0.001; ***p < 0.0001