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Fig. 3 | Health and Quality of Life Outcomes

Fig. 3

From: Clostridium difficile Infection–Daily Symptoms (CDI-DaySyms™) questionnaire: psychometric characteristics and responder thresholds

Fig. 3

Known-groups validity: ANOVA of CDI-DaySyms™ PRO questionnaire and the CGI-S and PGA-S scales at baseline. Pairwise comparisons between domain LS means were performed using Scheffé’s test adjusting for multiple comparisons. Comparisons were: 1 = Mild vs Moderate; 2 = Mild vs Severe; 3 = Mild vs Very Severe; 4 = Moderate vs Severe; 5 = Moderate vs Very Severe; 6 = Severe vs Very Severe. Significance levels: *p < 0.05; **p < 0.001; ***p < 0.0001. a Statistically-significant CGI-S pairwise comparisons were Diarrhea Symptoms for comparison = 1**; Abdominal Symptoms for comparison = 1***; and Systemic/Other Symptoms for comparison = 1**. b Statistically-significant PGA-S pairwise comparisons were Diarrhea Symptoms for comparisons = 2**, 3***, 4*, 5***; Abdominal Symptoms for comparisons = 2*, 3**, 5**; and Systemic/Other Symptoms for comparison = 5**. Abbreviations: ANOVA, Analysis of Variance; CDI-DaySyms™, Clostridium difficile Infection–Daily Symptoms; CGI-S, Clinical Global Impression of Severity; LS, least-square; PGA-S, Patient Global Assessment of Severity; PRO, patient-reported outcome

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