Table 4 Mean utility values and scores at weekly time points shown between baseline and week 8

EQ-5D-5L

N = 120

N = 81

N = 75

N = 74

N = 71

N = 65

N = 65

N = 64

N = 64

N = 64

0.64 (0.59,0.68)

0.65 (0.59,0.70)

0.70 (0.65,0.75)

0.72 (0.66,0.77)

0.74 (0.68,0.80)

0.76 (0.71,0.82)

0.77 (0.71,0.83)

0.78 (0.73,0.84)

0.72 (0.65,0.80)

P<0.007**

VAS

N = 120

N = 81

N = 75

N = 75

N = 73

N = 66

N = 65

N = 64

N = 64

N = 64

45.68 (42.34,49.02)

57.70 (53.36,62.05)

60.79 (56.03,65.54)

63.21 (59.01,67.42)

65.95 (61.01,70.88)

68.09 (63.36,72.83)

68.75 (64.19,73.32)

71.56 (66.99,76.14)

67.88 (62.58,73.17)

P<0.000**

AQLQ overall

N = 120

N = 70

N = 65

N = 65

3.28 (3.11,3.45)

4.09 (3.76,4.42)

4.48 (4.13,4.83)

P<0.000**

AQLQ Symptoms

N = 121

N = 85

N = 66

N = 66

2.81 (2.62,3.00)

3.33 (2.89,3.77)

3.64 (3.10,4.18)

P<0.003**

AQLQ Activity

N = 121

N = 85

N = 66

N = 66

3.51 (3.33,3.69)

3.32 (2.90,3.73)

3.68 (3.17,4.19)

P <0.044*

AQLQ Emotional

N = 121

N = 85

N = 66

N = 66

3.14 (2.87,3.40)

3.36 (2.88,3.84)

3.72 (3.14,4.31)

P <0.041*

AQLQ Environmental

N = 121

N = 85

N = 66

N = 66

4.04 (3.76,4.31)

3.63 (3.12,4.13)

3.91 (3.34,4.47)

P <0.089

AQL-5D

N = 118

N = 70

N = 64

N = 62

0.61 (0.59,0.63)

0.69 (0.65,0.73)

0.74 (0.69,0.78)

P<0.000**

TTO

N = 112

N = 87

N = 80

N = 80

0.63 (0.58,0.68)

0.82 (0.76,0.88)

0.79 (0.72,0.85)

P<0.000**