Development of a symptom assessment in patients with myelofibrosis: qualitative study findings

Table 5 Saturation grid for subjects with MF who are treatment naïve (n = 7)

Root Concept	Interviews 1–3 vs. Interviews 4–5 (first three interviews vs. next two)^a	Interviews 1–5 vs. Interviews 6–7 (first five interviews vs. last two)^a	Total^b	Saturation achieved
Fatigue and/or tiredness	2 vs. 2	4 vs. 2	6	Yes
Pain below the ribs on the left side	2 vs. 1	3 vs. 2	5
Enlarged spleen	2 vs. 1	3 vs. 1	4
Night sweats/general sweats	1 vs. 2	3 vs. 0	3
Weight loss	2 vs. 1	3 vs. 0	3
Itching	1 vs. 0	1 vs. 1	2
Appetite loss	1 vs. 0	1 vs. 0	1
Bone pain	1 vs. 0	1 vs. 0	1
Cold	1 vs. 0	1 vs. 0	1
Dizziness	1 vs. 0	1 vs. 0	1
Full quickly/filling up quickly	1 vs. 0	1 vs. 0	1
Joint pain	0 vs. 1	1 vs. 0	1
Rashes	1 vs. 0	1 vs. 0	1

^aSaturation is considered to be reached if a downward trend in the elicitation of new sign and symptom concepts is observed and no new concepts that are relevant (i.e., pertinent to the research question and/or not idiosyncratic to an individual subject) emerge in the final set of interviews. Saturation is considered questionable if new concepts emerge in the final quartile of interview. Subjects included in each group of interviews are as follows: Group 1 (01–01, 01–03, 01–04); Group 2 (01–11, 01–14); Group 3 (01–16, 01–17)
^bTotal number of subjects who reported the concept spontaneously

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