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Table 4 Saturation grid for subjects with MF who are treatment-experienced (n = 16)

From: Development of a symptom assessment in patients with myelofibrosis: qualitative study findings

Concepts

First four interviews vs. next foura

First eight interviews vs. next foura

First twelve interviews vs. next foura

Totalb

Saturation achievedc

Fatigue and/or tiredness

3 vs. 4

7 vs. 3

10 vs. 3

13

Yes

Enlarged spleen

1 vs. 2

3 vs. 2

5 vs. 3

8

Yes

Pain below the ribs on the left side and/or stomach pain and/or abdominal pain

1 vs. 2

3 vs. 0

3 vs. 3

6

Yes

Shortness of breath

4 vs. 0

4 vs. 1

5 vs. 1

6

Yes

Muscle pain and/or muscle cramps

1 vs. 2

3 vs. 0

3 vs. 2

5

Yes

Bone pain

0 vs. 1

1 vs. 1

2 vs. 2

4

Yes

Itching

1 vs. 1

2 vs. 1

3 vs. 1

4

Yes

Night sweats/general sweats

1 vs. 2

3 vs. 1

4 vs. 0

4

Yes

Uncomfortable abdomen and/or abdominal discomfort and/or bloating and/or feeling full

0 vs. 2

2 vs. 0

2 vs. 2

4

Yes

Bruise easily

1 vs. 1

2 vs. 0

2 vs. 1

3

Yes

Dizziness

2 vs. 0

2 vs. 1

3 vs. 0

3

Yes

Balance

2 vs. 0

2 vs. 0

2 vs. 0

2

Yes

Brain fog

0 vs. 0

0 vs. 0

0 vs. 2

2

Questionable

Frequent urination

1 vs. 0

1 vs. 1

2 vs. 0

2

Yes

Full quickly and/or filling up quickly and/or eating less

0 vs. 1

1 vs. 0

1 vs. 1

2

Yes

Muscle weakness

1 vs. 0

1 vs. 1

2 vs. 0

2

Yes

Peripheral neuropathy

0 vs. 2

2 vs. 0

2 vs. 0

2

Yes

Achiness

0 vs. 0

0 vs. 1

1 vs. 0

1

Yes

Back pain

1 vs. 0

1 vs. 0

1 vs. 0

1

Yes

Burning sensation

0 vs. 1

1 vs. 0

1 vs. 0

1

Yes

Fevers/chills

0 vs. 0

0 vs. 1

1 vs. 0

1

Yes

Gout

0 vs. 0

0 vs. 1

1 vs. 0

1

Yes

Hand pain

0 vs. 0

0 vs. 0

0 vs. 1

1

Questionable

Headaches

0 vs. 0

0 vs. 0

0 vs. 1

1

Questionable

Hot flashes

0 vs. 1

1 vs. 0

1 vs. 0

1

Yes

Inflammation in arm

1 vs. 0

1 vs. 0

1 vs. 0

1

Yes

Joint pain

0 vs. 0

0 vs. 0

0 vs. 1

1

Questionable

Weight loss

0 vs. 0

0 vs. 0

0 vs. 1

1

Questionable

  1. aSaturation is considered to be reached if a downward trend in the elicitation of new sign and symptom concepts is observed and no new concepts that are relevant (i.e., pertinent to the research question and/or not idiosyncratic to an individual subject) emerge in the final set of interviews. Saturation is considered questionable if new concepts emerge in the final quartile of interview. Subjects included in each group of interviews are as follows: Group 1 (01–05, 01–02, 01–09, and 01–07); Group 2 (03–01, 05–01, 05–02, and 04–01); Group 3 (05–04, 05–05, 05–03, and 04–03); and Group 4 (04–02, 05–07, 03–07, and 03–09)
  2. bTotal number of subjects who reported the concept spontaneously
  3. cQuestionable: concepts were considered not relevant to the research question and/or were idiosyncratic to the individual patient