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Table 6 GRADE Summary of findings. Outcome: Bowel symptoms

From: Quality of life in bladder cancer patients receiving medical oncological treatment; a systematic review of the literature

 

GRADE issues

Overall GRADE rating

 

Nb. of studies

Risk of bias

Inconsistency

Indirectness

Imprecision

Publication bias

 

Before diagnosis

0

N/A

Before treatment

1 [18]

X1

  

X2

 

During treatment

2 [16, 18]

 

X3

X4

X2

 

≤ 6 months after treatment

1 [18]

X1

  

X2

 

> 6 months after treatment

7 [20, 21, 23,24,25,26, 35]

 

X5

  

None apparent6

  1. 1Only one study represented
  2. 2Small number of patients
  3. 3Large difference in populations hence diverging scores, despite same instrument used
  4. 4Only one study representing metastatic population, no studies representing neoadjuvant population
  5. 5Large range between scores despite comparable study populations, presumably due to different instruments used, incl. Non-validated instruments
  6. 6As estimated by funnel plot