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Table 4 Information including number of patients included and analyzed and anchor used for each study selected (N = 46)

From: Distribution- and anchor-based methods to determine the minimally important difference on patient-reported outcome questionnaires in oncology: a structured review

Reference Number of patients included Number of patients included in the analysis (range for multiple analyses) Questionnaires on which the MID was determined Anchor
Askew, R.L. (2009) [19] 273 163 FACT-M Performance status
Bédard, G. (2014) [21] 369 367 to 369 EORTC QLQ-C30 Global HRQOL dimension of the QLQ-C30
Bédard, G. (2016) [22] 276 276 EORTC QLQ-C15-PAL Global HRQOL dimension of the QLQ-C15 PAL
Bédard, G. (2016) [22] 421 197 to 276 EDMONTON SYMPTOM ASSESSMENT SYSTEM (ESAS) Well-being dimension of the ESAS
Bharmal, M. (2017) [23] 88 70 FACT-M Percentage change in tumor size
Binenbaum, T. (2014) [24] 1011 329 to 631 UW-QOLQ, EORTC QLQ-C30, QLQ-H&N35 No anchor used
Cella, D. (2009) [26] 809 809 FACT-P Performance status
Cella, D. (2002) [13] 50; 50 to 2402 FACT-AN Performance status; hemoglobin level
Cella, D. (2002) [25] 599 573 FACT-L Best overall response to treatment, time to disease progression
Chan, A. (2018) [27] 257 201 MFSI-SF Fatigue dimension of the QLQ-C30
Cheung, Y.T. (2014) [28] 330 220 FACT-Cog Cognitive dimension of the QLQ-C30
Den Oudsten, B.L. (2013) [29] 606 355 WHOQOL-100 QoL of the WHOQoL
Eton, D.T. (2007) [32] 92 91 FACT-G, FACT-Lung Symptom Index-12 Performance status
Eton, D.T. (2006) [30] 209 209 FACT-BRM Clinical distinct groups using performance status
Eton, D.T. (2004) [31] 771 128 to 643 FACT-B Performance status, physician assessment of current pain, and response to treatment
Granger, C.L. (2015) [34] 69 69 Physical Activity Scale For The Elderly (PASE) No anchor used
Granger, C.L. (2015) [33] 56 63 to 66 6-Minute Walk Distance Physical functioning dimension of the QLQ-C30
Hong, F. (2013) [35] 765 627 EORTC QLQ-C30 Patient’s rating of change
Hui, D. (2016) [36] 796 792 to 795 Edmonton Symptom Assessment System (ESAS) Patient’s rating of change
Jayadevappa, R. (2012) [37] 602 528 SF-36, UCLA Prostate Cancer Index (PCI) A patient-reported physical signs/symptoms (more tired or worn out than usual)
Kemmler, G. (2010) [38] 187 160 EORTC QLQ-C30 Patient’s rating of change
Lemieux, J. (2007) [39] 235 133 EORTC QLQ-C30, POMS, MAC, IES, PAIS, PAIN No anchor used
Liu, H. (2015) [40] 2440 ≤ 246 2 single-item questions Patient’s rating of change
Maringwa, J.T (2011) [41] 941 420 to 572 EORTC QLQ-C30, QLQ-BN20 Performance status; MMSE
Maringwa, J.T (2011) [41] 812 410 to 519 EORTC QLQ-C30 Performance status; weight change
Mathias, S.D. (2011) [42] 2049 1564 Brief Pain Inventory-Short Form (BPI-SF) BPI-SF current pain and EQ-5D index score
Mouysset, J.L. (2016) [43] 1262 510 FACT-F VAS of fatigue
Ousmen, A. (2016) [62] 381 74 to 260 EORTC QLQ-C30; QLQ-BR23 Patient’s rating of change
Pickard, A.S. (2007) [44] 534 534 EQ-5D Performance status
Purcell, A. (2010) [45] 210 157 to 199 MFI-20 VAS of the EQ-5D; performance status; treatment impact on fatigue
Raman, S. (2016) [46] 298 201 to 204 EORTC QLQ-BM22, QLQ-C15-PAL Global HRQOL dimension of the QLQ-C15 PAL
Raman, S. (2018) [47] 850 360 to 375 EORTC QLQ-C30, BPI Global HRQOL dimension of the QLQ-C30
Sagberg, L.M. (2014) [48] 173 142 to 164 EQ-5D 3 L Performance status
Shun, S.C (2007) [49] 243 148 3 fatigue instruments Patient’s rating of change
Skolarus, T.A. (2015) [50] 1201 1201 EPIC-26 Item from the service satisfaction scale for cancer care scale
Steel, J. L. (2006) [51] 158 158 FACT-HEP Alpha-fetoprotein, alkaline phosphate and hemoglobin levels, survival
Tamminga, S.J. (2014) [52] 53 43 Work Limitations Questionnaire (WLQ) Patient’s rating of change
Tsiplova, K. (2016) [53] 3770 3765 EQ-5D Global health question
Tuomi, L. (2016) [54] 126 119 Swedish self-evaluation of communication experiences after laryngeal cancer (S-SECEL) Acceptability of speech in a social context
Wong, E. (2015) [55] 99 77 to 99 EORTC QLQ-BN20 Item 30 of the QLQ-C30 or 15 of QLQ-C15 PAL
Wong, K. (2013) [56] 414 153 to 233 Brief Pain Inventory (BPI) Pain score of the BPI
Wright, P. (2008) [57] 276 187 Social Difficulty Inventory Social functioning dimension of the QLQ-C30
Yost, K.J. (2005) [58] 200 144 to 164 FACT-BRM Patient’s rating of change; performance status
Yost, K.J. (2005) [58] 60 60 to 568 FACT-C Performance status
Yost, K.J. (2011) [59] 101 88 to 101 PROMIS-cancer scales Patient’s rating of change; performance status; 21 other anchors
Zeng, L. (2012) [61] 400 88 to 93 EORTC QLQ-C30, QLQ-BM22 Performance status