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Table 4 Mixed effect model analysis of metformin effect on PCOS-specific HRQoL measured via Chi-PCOSQ

From: Correction to: Metformin improved health-related quality of life in ethnic Chinese women with polycystic ovary syndrome

Chi-PCOSQ Total
Coefficient (SE)
Subgroups
Normal weight
Coefficient (SE)
Overweight
Coefficient (SE)
Non- hyperandrogenism
Coefficient (SE)
Hyperandrogenism
Coefficient (SE)
Total scores
 Treatment time      
  Visit 2 (reference = visit 1) 0.44 (0.56) 0.75 (0.86) 0.20 (0.75) −0.58 (0.89) 0.61 (0.66)
  Visit 3 (reference = visit 1) 1.25 (0.56) 1.77 (0.84) 0.80 (0.78) 0.11 (0.92) 1.45 (0.66)*
Weight domain
 Treatment time      
  Visit 2 (reference = visit 1) −0.06 (0.14) 0.11 (0.22) −0.18 (0.19) −0.04 (0.28) −0.07 (0.17)
  Visit 3 (reference = visit 1) 0.12 (0.15) 0.15 (0.21) 0.10 (0.20) −0.01 (0.29) 0.15 (0.17)
Infertility domain
 Treatment time p = 0.043     p = 0.048
  Visit 2 (reference = visit 1) 0.25 (0.18) 0.34 (0.23) 0.15 (0.29) −0.06 (0.33) 0.32 (0.21)
  Visit 3 (reference = visit 1) 0.46 (0.18)* 0.34 (0.24) 0.59 (0.28)* 0.12 (0.34) 0.52 (0.21)*
Menstrual domain
 Treatment time      
  Visit 2 (reference = visit 1) 0.10 (0.18) 0.21 (0.29) 0.02 (0.24) 0.26 (0.39) 0.08 (0.20)
  Visit 3 (reference = visit 1) 0.19 (0.18) 0.36 (0.27) 0.04 (0.25) 0.58 (0.41) 0.11 (0.20)
Emotions domain
 Treatment time      
  Visit 2 (reference = visit 1) 0.07 (0.15) 0.15 (0.21) 0.01 (0.21) 0.82 (0.33)* 0.04 (0.18)
  Visit 3 (reference = visit 1) 0.14 (0.15) 0.30 (0.21) 0.003 (0.21) 0.43 (0.29) 0.13 (0.18)
Body hair domain
 Treatment time      
  Visit 2 (reference = visit 1) 0.03 (0.14) 0.18 (0.19) −0.08 (0.20) −0.34 (0.20) 0.10 (0.17)
  Visit 3 (reference = visit 1) 0.02 (0.14) 0.24 (0.18) −0.16 (0.21) −0.37 (0.21) 0.10 (0.17)
Acne & Hair loss domain
 Treatment time p = 0.008   p = 0.043   p = 0.007
  Visit 2 (reference = visit 1) −0.51 (0.28) −0.10 (0.19) 0.01 (0.20) −0.46 (0.18)* −0.55 (0.35)
  Visit 3 (reference = visit 1) 0.45 (0.26) 0.08 (0.19) 0.33 (0.21) −0.28 (0.19) 0.71 (0.32)*
  1. Note: Visit 1 is 1st office visit when patients were diagnosed with PCOS (baseline). Once PCOS was diagnosed, patients started metformin treatment. Visit 2 was 2nd office visit (1st-2nd month of treatment). Visit 3 was 3rd office visit (3rd- 4th month of treatment). The analysis was adjusted for the effect of medication adherence via the Morisky 8-item medication adherence scale
  2. Abbreviations: PCOS polycystic ovary syndrome, HRQoL Health related Quality of life, SE standard error
  3. *p < 0.05