Assessing utility values for treatment-related health states of acute myeloid leukemia in the United States

Table 6 Preferences for Features of AML Health States^a

Features	Coefficient	OR	95% CI	p
Duration of life (years)	0.108	1.115	(1.09, 1.14)	< 0.001*
Fever
Occasionally vs. frequently	0.022	1.022	(0.91, 1.15)	0.722
Rarely/never vs. frequently	0.235	1.265	(1.12, 1.43)	< 0.001*
Lack of energy
Frequently vs. all the time	0.015	1.015	(0.90, 1.14)	0.795
Occasionally vs. all the time	0.098	1.103	(0.97, 1.26)	0.149
Problems with daily function
Not being able to perform daily activities but able to self-care (i.e., washing and dressing oneself) vs. not being able to take care of self, bedridden most of the time	0.581	1.788	(1.50, 2.13)	< 0.001*
Not able to work but able to perform daily activities vs. not being able to take care of self, bedridden most of the time	0.887	2.428	(2.01, 2.93)	< 0.001*
Able to work normally vs. not being able to take care of self, bedridden most of the time	1.173	3.233	(2.64, 3.96)	< 0.001*
Anxious/depressed
Occasionally vs. frequently	0.065	1.067	(0.96, 1.19)	0.242
Blood transfusion
Occasionally vs. frequently	0.141	1.152	(1.02, 1.30)	0.025*
Rarely/never vs. frequently	0.167	1.181	(1.05, 1.33)	0.008*
Hospitalized
Frequently/occasionally vs. all the time	0.347	1.415	(1.23, 1.63)	< 0.001*
Rarely/never vs. all the time	0.553	1.738	(1.46, 2.06)	< 0.001*
Avoiding risk of chemotherapy-related SAEs
Serious infection	0.287	1.332	(1.21, 1.47)	< 0.001*
Severe diarrhea	0.225	1.252	(1.12, 1.39)	< 0.001*
Severe redness/skin peeling	0.071	1.073	(0.98, 1.18)	0.136
Abnormally low blood cell counts	0.121	1.129	(1.01, 1.26)	0.034*

*p < 0.05; Abbreviations: SAEs serious adverse events, CI confidence interval, OR odds ratio
^aThe estimated intercept in this model is − 0.134

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