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Table 2 Reliability of the Localized Scleroderma Cutaneous Assessment Tool components and global assessment of disease tools

From: Localized Scleroderma Cutaneous Assessment Tool (LoSCAT) adapted for use in adult patients: report from an initial validation study

  Inter-rater reliability Intra-rater reliability
Cohen’s kappa statistics* (95% CI) Intraclass correlation coefficient* (95% CI) Spearman’s correlation coefficient* (95% CI)
mLoSSI 0.8936 (0.85, 0.93) 0,9937 (0.98, 0.99) 0,9739 (NA)
 New lesion/lesion extension (N/E) 1 (1.00) 1 (1.00) 1 (NA)
 Erythema (ER) 0.8096 (0.74, 0.88) 0.9862 (0.97, 0.99) 0.953 (NA)
 Skin thickness (ST) 0.8991 (0.85, 0.95) 0.9932 (0.98, 0.99) 0.974 (NA)
LoSDI 0.8707 (0.82, 0.92) 0.9937 (0.98, 0.99) 0.9886 (NA)
 Dermal atrophy (DAT) 0.9196 (0.87, 0.97) 0.9948 (0.99) 0.9741 (NA)
 Subcutaneous atrophy (SAT) 0.9058 (0.86, 0.96) 0.9909 (0.98, 0.99) 0.9744 (NA)
 Dyspigmentation (DP) 0.8227 (0.75, 0.90) 0.9746 (0.95, 0.98) 0.9823 (NA)
PhysGA-A 0.7406 (0.46, 092) 0.9647 (0.93, 0.98) 0.8939 (0.80, 0.94)
PhysGA-D 0.7109 (0.42, 0.91) 0.9532 (0.90, 0.98) 0.7118 (0.50, 0.84)
  1. CI confidence interval, mLoSSI modified Localized Scleroderma Skin Severity Index, LoSDI Localized Scleroderma Damage Index, PhysGA-A physician global assessment of disease activity, PhysGA-D physician global assessment of disease damage
  2. *p < 0.000001