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Table 4 MCID estimates for minimally improved patients as indicated on the GRC during follow-up

From: Assessing health status over time: impact of recall period and anchor question on the minimal clinically important difference of copd health status tools

Measurement period

N

CAT

CAT Standardized

CCQ Total

CCQ Total Standardized

SGRQ Total

15-point GRC T1-T0

196

−3.1*±5.3

(− 3.9 to − 2.4)

− 7.8*±13.2

(− 9.7 to − 5.9)

−0.6*±0.8

(− 0.7 to − 0.4)

− 9.3*±14.0

(− 11.3 to − 7.3)

− 8.4*±11.8

(− 10.1 to − 6.7)

15-point GRC T2-T0

107

−2.7*±6.4

(− 4.0 to − 1.5)

−6.9*±16.1

(− 9.9 to − 3.8)

−0.4*±1.0

(− 0.6 to − 0.2)

− 7.3*±16.8

(− 10.5 to − 4.0)

− 7.6*±13.8

(− 10.2 to − 4.9)

15-point GRC T3-T0

96

− 2.7*±6.7

(− 4.1 to − 1.4)

−6.8*±16.7

(− 10.2 to − 3.5)

−0.4*±1.1

(− 0.6 to − 0.2)

− 7.0*±18.0

(− 10.6 to − 3.3)

− 9.2*±14.0

(− 12.1 to − 6.3)

15-point GRC T4-T0

80

−2.3*±6.1

(− 3.7 to − 1.0)

−5.8*±15.2

(− 9.2 to − 2.4)

−0.5*±0.8

(− 0.7 to − 0.3)

− 7.6*±13.8

(− 10.8 to − 4.7)

− 10.3*±12.9

(− 13.2 to − 7.4)

15-point GRC T5-T0

88

−2.8*±6.7

(− 4.2 to − 1.4)

−7.0*±16.7

(− 10.5 to − 3.5)

− 0.5*±1.0

(− 0.7 to − 0.3)

− 8.3*±16.3

(− 11.7 to − 4.8)

− 8.8*±14.1

(− 11.8 to − 5.8)

Five-point GRC T5-T0

81

−1.4*±5.9

(− 2.7 to − 0.1)

−3.5*±14.7

(− 6.7 to − 0.3)

−0.3*±0.8

(− 0.5 to − 0.2)

− 5.5*±13.8

(− 8.7 to − 2.5)

−7.7*±12.9

(− 10.5 to − 4.8)

  1. Minimal change scores reported as mean ± SD (95%CI). Change is measured compared to baseline. Negative values represent improvement for CAT, CCQ and SGRQ. CAT and CCQ were standardized into a scale from zero to 100 to be comparable with SGRQ
  2. *Significance of change scores p < 0.05 at T1/T2/T3/T4/T5 compared to baseline (T0)
  3. 95%CI 95% Confidence Interval, CAT COPD Assessment Test, CCQ Clinical COPD Questionnaire, GRC Global Rating of Change scale, N number of patients, SD Standard Deviation, SGRQ St. George’s Respiratory Questionnaire, T0 Measurement at baseline, T1 Measurement at discharge, T2 3 months follow-up, T3 6 months follow-up, T4 9 months follow-up, T5 12 months follow-up