Fig. 2

Domain-level grouping created from the responses gathered from patients and significant others. Our domain-level groupings are mapped into the category headings given by the World Health Organization (see headings in capital letters in the top row). Domain-level grouping in the bottom row could not easily be fitted into the WHO nomenclature. Multi-attribute categories are given in bold font; with any denoted with an open bullet point (o) indicating additional multi-attribute domains that have been grouped within the same category. Closed bullet points (●) indicate discrete unidimensional patient-reported domains arising from the data collected. The superscript numbers indicate how many studies in total identified that domain (e.g. ⁿ¹¹). An open square (□) denotes that the domain was identified using an open-question format. A crossed square (⊠) denotes that the domain was identified using a closed-question format