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Table 1 Characteristics of included studies

From: Health-related quality of life among long-term (≥5 years) prostate cancer survivors by primary intervention: a systematic review

 

At survey ≥5 years

Mean/ Median (Range)a

At diagnosisg

First Author/ Year, Country

Study Design

Sample

Size (n)

Intervention (%)

Age at survey (years)

Follow-up timef

(years)

Cancer Stage (%)

Berg, A/ 2007,

Norway [35]

Hospital-based observational prospective monocentric cohort study

64

EBRT (100) [+ADT (44.0)]e

66c

(48-81)

11

(10-16)

Localized PC (33.0)

Locally advanced PC (67.0)

Brundage, M/ 2015, UK and US [36]

Hospital-based mulitcentric randomized controlled trial

85-111d

1. ADT (50.0)c

2. ADT + EBRT (50.0)c

69.7c

(65.5

−73.5)

(5-8)

Locally advanced PC (100.0)

Donovan, J L / 2016, UK [37]

Population-based multicentric randomized controlled trial

1413-1463d

1. AS (33.2)

2. RP (33.7)

3. EBRT (33.1)

62c

(5-6)

Localized PC (100.0)

Fransson, P/ 2008, Sweden [38]

Hospital-based observational prospective monocentric cohort study

64

1. EBRT (42.2) + ADT (20.3)

2. Controls (57.8)

78.1

(62-87)

14.7

(13.5 – 16.4)

Localized PC (89.9)

Locally advanced PC (11.1)

Fransson, P/ 2009, Sweden [39]

Hospital-based observational monocentric retrospective cohort study

54

1. EBRT (50.0)

2. WW (50.0)

78

(54 – 88)

9.6

(6.4-16.3)

Local PC (100.0)

Galbraith, M E/ 2005, US [40]

Hospital-based observational prospective monocentric cohort study

137

1. WW (11.5)c

2. RP (21.4)c

3. EBRT – C (9.9)b,c

4. EBRT - PB (11.5)b,c

5. EBRT - MB (20.3)b,c

6. EBRT -LD (13.7)b,c

7. EBRT - HD (17)b,c

69.9c

5.5

No information

Giberti, C/ 2009, Italy [41]

Hospital-based monocentric randomized controlled trial

174

1. RP (44.5)

2. BT (55.5)

65.3c

(56-74)c

5

Localized PC (100.0)

Johnstone, P A S/ 2000, US [42]

Hospital based observational monocentric prospective cohort study

46

EBRT (100.0)

[+ ADT (43.5)]e

80

(62-90)

13.9

(10 - 23)

Localized PC

Locally advanced PC

Mols, F/ 2006,

Denmark [43]

Population-based observational retrospective cohort study

780

1. RP (32.9)

2. EBRT (41.4)

3. ADT (13.7)

4. EBRT (11.9)

75

(5-10)

Localized PC (76.0)

Locally Advanced PC (18.0)

Unknown (6.0)

Namiki, S/ 2011,

Japan [44]

Hospital-based observational prospective monocentric cohort study

111

1. RP (43.2) + ADT (48)

2. EBRT (56.8) + ADT (100.0)

69.5c

(53 – 84)

5

Locally Advanced PC (100.0)

Namiki, S/ 2014,

Japan [45]

Hospital-based observational prospective monocentric cohort study

91

RP (100.0)

63.9c

8.5

(7.1 - 10.25)

Localized PC (94.5)

Locally Advanced PC (5.5)

Shinohara, N/ 2013, Japan [46]

Hospital-based observational monocentric prospective cohort study

67

1. EBRT (32.4)

2. RP (67.6)

68c

(53-79)

5

Localized PC (93.4)

Locally Advanced PC (6.6)

Thong, M S/ 2010, Nether-lands [47]

Population-based observational retrospective cohort study

142

1. AS (50.0) [+ ADT (2.8)/ +RP (1.4)/ + EBRT (7)/ + EBRT + ADT (1.4)]e

2. EBRT (50.0) + [RP (7)/ + ADT (2.8)/ + EBRT (1.4) + EBRT + ADT (1.4)]e

75.8

7.8

Localized PC (100.0)

  1. RP Radical Prostatectomy, EBRT External Beam Radiotherapy (refers to the external delivery of any type of radiation), BT Brachytherapy, WW Watchful Waiting, AS Active Surveillance, ADT Androgen Deprivation Therapy
  2. aMean/Median for total sample
  3. bEBRT-C — Conventional radiation; EBRT-HD — High-dose mixed-beam radiation; EBRT-LD — Low-dose mixed-beam radiation; EBRT-MB — Standard protocol/mixed-beam radiation; EBRT-PB — Proton beam radiation
  4. cSample size/Age at enrolment in study or randomization
  5. dSample sizes at different time points ≥ 5 years
  6. eSecondary intervention(s)
  7. fEither time since diagnosis or time since randomization
  8. gCategorization: local PC – T1 & T2, locally advanced PC T3 & T4
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Health and Quality of Life Outcomes

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