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Table 6 Responder analysis based on various MID methods

From: Psychometric properties of the FACT-M questionnaire in patients with Merkel cell carcinoma

FACT-M Subscales and Summary scores   Percentage of responders[a] at Week 7 by MID calculation method
  SEM[b] Anchor[c] Minimum threshold Maximum threshold
FACT-G subscales
 Physical well-being (PWB) 18.4 32.7 32.7 18.4
 Social/Family well-being (SWB) 22.4 53.1 53.1 18.4
 Emotional well-being (EWB) 34.7 34.7 44.9 26.5
 Functional well-being (FWB) 30.6 30.6 34.7 22.4
Melanoma-specific subscales
 Melanoma Subscale (MS) 22.4 26.5 34.7 20.4
 Melanoma surgery scale (MSS) 22.4 22.4 30.6 20.4
Summary scales
 FACT-M TOI 24.5 22.4 30.6 14.3
 FACT-G total score 30.6 34.7 34.7 20.4
 FACT-M total score 28.6 28.6 28.6 14.3
MCC-Specific scores
 Physical Function score (PF) 18.4 26.5 26.5 12.2
 Psychological Impact score (PI) 38.8 51.0 51.0 26.5
 MCC summary score 24.5 30.6 30.6 18.4
  1. MCC Merkel cell carcinoma, MID Minimally important difference, PAS PRO analysis set, SEM Standard error of measurement, TOI Trial Outcome Index
  2. Percentage of responders were assessed in the PAS (N = 70)
  3. [a]A responder is defined as a patient whose score had changed relative to baseline by an amount greater than or equal to the MID; [b]SEM was calculated using Cronbach's alpha for internal consistency reliability; [c]Reduction in tumor size ≥30% was used as the anchor for MID thresholds