Psychometric properties of the FACT-M questionnaire in patients with Merkel cell carcinoma

Table 6 Responder analysis based on various MID methods

FACT-M Subscales and Summary scores		Percentage of responders^[a] at Week 7 by MID calculation method
	SEM^[b]	Anchor^[c]	Minimum threshold	Maximum threshold
FACT-G subscales
Physical well-being (PWB)	18.4	32.7	32.7	18.4
Social/Family well-being (SWB)	22.4	53.1	53.1	18.4
Emotional well-being (EWB)	34.7	34.7	44.9	26.5
Functional well-being (FWB)	30.6	30.6	34.7	22.4
Melanoma-specific subscales
Melanoma Subscale (MS)	22.4	26.5	34.7	20.4
Melanoma surgery scale (MSS)	22.4	22.4	30.6	20.4
Summary scales
FACT-M TOI	24.5	22.4	30.6	14.3
FACT-G total score	30.6	34.7	34.7	20.4
FACT-M total score	28.6	28.6	28.6	14.3
MCC-Specific scores
Physical Function score (PF)	18.4	26.5	26.5	12.2
Psychological Impact score (PI)	38.8	51.0	51.0	26.5
MCC summary score	24.5	30.6	30.6	18.4

MCC Merkel cell carcinoma, MID Minimally important difference, PAS PRO analysis set, SEM Standard error of measurement, TOI Trial Outcome Index
Percentage of responders were assessed in the PAS (N = 70)
^[a]A responder is defined as a patient whose score had changed relative to baseline by an amount greater than or equal to the MID; ^[b]SEM was calculated using Cronbach's alpha for internal consistency reliability; ^[c]Reduction in tumor size ≥30% was used as the anchor for MID thresholds

ISSN: 1477-7525