From: Psychometric properties of the FACT-M questionnaire in patients with Merkel cell carcinoma
FACT-M Subscales and Summary scores | Comparison of change in score from baseline to Week 7 Percent change in tumor size (mean change in score [ES[a]]) | MIDs assessed at Week 7 | Published MIDs in melanoma population | ||||||
---|---|---|---|---|---|---|---|---|---|
Change in tumor size | 0.2 x SDBL | 0.5 x SDBL | SEM[d] | Range(min-max) | |||||
Reduction ≥ 30%[b] (N = 14) | Reduction between 0-30% (N = 7) | Increase >0% (N = 16) | p-value[c] | ||||||
FACT-G subscales | |||||||||
Physical well-being (PWB) | 0.21 (0.05) | -1.00 (-0.18) | -1.75 (-0.31) | 0.631 | 1.14 | 2.85 | 2.15 | 0.21 - 2.85 | 2.00-3.00[e] |
Social/Family well-being (SWB) | -0.49 (-0.10) | -0.45 (-0.12) | -1.74 (-0.28) | 0.624 | 1.01 | 2.52 | 2.21 | -0.49 - 2.52 | - |
Emotional well-being (EWB) | 1.07 (0.22) | 1.29 (0.20) | -0.25 (-0.09) | 0.596 | 0.91 | 2.28 | 1.87 | 0.91 - 2.28 | 2.00[e] |
Functional well-being (FWB) | 2.64 (0.42) | -0.14 (-0.02) | -2.81 (-0.42) | 0.005 | 1.27 | 3.19 | 2.26 | 1.27 - 3.19 | 2.00-3.00[e] |
Melanoma-specific subscales | |||||||||
Melanoma Subscale (MS) | 2.71 (0.26) | -2.43 (-0.36) | -2.94 (-0.42) | 0.051 | 1.80 | 4.50 | 3.46 | 1.80 - 4.50 | 2.00-4.00[f] |
Melanoma surgery scale (MSS) | 2.07 (0.34) | -3.00 (-1.02) | -3.13 (-0.49) | 0.036 | 1.22 | 3.05 | 2.46 | 1.22 - 3.05 | 1.00-2.00[f] |
Summary scales | |||||||||
FACT-M TOI | 5.57 (0.31) | -3.57 (-0.21) | -7.50 (-0.42) | 0.038 | 3.86 | 9.64 | 4.84 | 3.86 - 9.64 | 5.00-9.00[f] |
FACT-G total score | 3.44 (0.21) | -0.31 (-0.02) | -6.55 (-0.35) | 0.155 | 3.54 | 8.85 | 4.24 | 3.44 - 8.85 | 3.00-7.00[e] |
FACT-M total score | 6.15 (0.26) | -2.74 (-0.12) | -9.49 (-0.38) | 0.074 | 5.05 | 12.62 | 5.26 | 5.05 - 12.62 | - |
MCC-Specific scores | |||||||||
Physical Function score (PF) | 0.71 (0.14) | -1.86 (-0.33) | -2.13 (-0.34) | 0.153 | 1.15 | 2.87 | 1.88 | 0.71 - 2.87 | - |
Psychological Impact score (PI) | 0.79 (0.15) | 2.29 (0.39) | 0.31 (0.10) | 0.609 | 0.95 | 2.38 | 1.98 | 0.79 - 2.38 | - |
MCC summary score | 1.50 (0.17) | 0.43 (0.04) | -1.81 (-0.21) | 0.530 | 1.91 | 4.76 | 2.91 | 1.50 - 4.76 | - |