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Table 6 Change from Day 1 to Week 12 among ACR20 and DAS28-hsCRP Groups

From: Psychometric properties of morning joint stiffness duration and severity measures in patients with moderately to severely active rheumatoid arthritis

PRO/Study/Statistics

ACR20 Category at Week 12

P-value, ES

DAS28-hsCRP Groups at Week 12b

Comparisons, ESc

Respondera

Nonrespondera

DAS28-hsCRP <2.6

2.6 ≤ DAS28-hsCRP <3.2

DAS28-hsCRP ≥3.2

Duration of MJS

 RA-BEAM

  N, Mean (SD)

326, −84.2 (167.5)

211, −17.2 (166.4)

 

88, −92.4 (185.0)

79, −84.0 (170.1)

368, −44.2 (165.4)

 

  Median d

−35.1

−7.0

0.001, −0.40

−55.0

−30.0

−12.6

a: 0.809, −0.05

b: 0.001, −0.28

c: 0.001, −0.24

 RA-BUILD

  N, Mean (SD)

174, −70.1 (139.3)

137, −19.6 (196.8)

 

61, −87.9 (133.7)

33, −65.7 (96.7)

214, −34.1 (185.0)

 

  Median d

−42.9

−9.1

0.001, −0.30

−50.7

−40.0

−26.9

a: 0.221, −0.18

b: 0.001, −0.31

c: 0.022, −0.18

Severity of MJS

 RA-BEAM

  N, Mean (SD)

326, −3.2 (2.3)

211, −1.1 (2.2)

0.001, −0.90

88, −3.7 (2.3)

79, −3.1 (2.3)

368, −1.9 (2.4)

a: 0.083, −0.25

b: 0.001, −0.76

c: 0.001, −0.52

 RA-BUILD

  N, Mean (SD)

175, −2.9 (2.3)

137, −1.0 (2.1)

0.001, −0.85

61, −3.1 (2.5)

33, −2.6 (2.6)

215, −1.8 (2.2)

a: 0.264, −0.21

b: 0.001, −0.59

c: 0.002, −0.35

  1. Abbreviations: ACR20 20% improvement in American College of Rheumatology criteria, DAS28 Disease Activity Score modified to include the 28 diarthrodial joint count, hsCRP high-sensitivity C-reactive protein, MJS morning joint stiffness, SD standard deviation, ES effect size
  2. aResponder: Achievement of ACR20 criteria at Week 12; Nonresponder: Failure to achieve ACR20 criteria at Week 12
  3. bMissing DAS28-hsCRP at Week 12 was imputed using modified baseline observation carried forward
  4. cNote for multiple comparison: a: <2.6 vs. ≥2.6 and <3.2; b: <2.6 vs. ≥3.2; c: ≥2.6 and <3.2 vs. ≥3.2
  5. dDaily average of 7 days preceding visit that contained at least 4 measurements
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Health and Quality of Life Outcomes

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