Psychometric properties of the single-item measure, severity of worst tiredness, in patients with moderately to severely active rheumatoid arthritis

Table 8 Change in Severity of Worst Tiredness from Day 1 to Week 12 among ACR20 and DAS28-hsCRP Groups

PRO/Study/Statistics	ACR20 Category at Week 12		p-value	DAS28-hsCRP Groups at Week 12^b			Comparisons^c
PRO/Study/Statistics	Responder^a	Nonresponder^a	p-value	DAS28-hsCRP < 2.6	2.6 ≤ DAS28-hsCRP < 3.2	DAS28-hsCRP ≥ 3.2	Comparisons^c
RA-BEAM; N, Mean (SD)	326, −2.5 (2.5)	211, −1.0 (2.1)	0.001	88, −3.1 (2.7)	79, −2.4 (2.4)	368, −1.5 (2.3)	a: 0.069; b: 0.001; c: 0.001
RA-BUILD; N, Mean (SD)	174, −2.6 (2.6)	137, −0.9 (2.0)	0.001	61, −2.9 (2.8)	33, −2.6 (3.2)	214, −1.5 (2.2)	a: 0.846; b: 0.001; c: 0.001

Abbreviations: ACR20 = 20% improvement in American College of Rheumatology criteria; DAS28 = Disease Activity Score modified to include the 28 diarthrodial joint count; hsCRP = high-sensitivity C-reactive protein; SD = standard deviation
^aResponder: Achievement of ACR20 criteria at Week 12; Nonresponder: Failure to achieve ACR20 criteria at Week 12
^bMissing DAS28-hsCRP at Week 12 was imputed using modified baseline observation carried forward
^cNote for multiple comparison: a: <2.6 vs. ≥2.6 and <3.2; b: <2.6 vs. ≥3.2; c: ≥2.6 and <3.2 vs. ≥3.2
^dDaily average of seven days preceding visit that contained at least 4 measurements

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